Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2005-12-22
2008-12-30
Campell, Bruce (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C424S204100, C424S193100, C424S207100
Reexamination Certificate
active
07470777
ABSTRACT:
Embodiments of the invention include compositions comprising and methods utilizing a retroviral integrase complex comprising a recombinant integrase having a domain comprising a non-native protein binding site, and a DNA binding protein comprising a DNA binding domain and a peptide binding domain that binds the non-native protein binding site of the recombinant integrase.
REFERENCES:
patent: 5339346 (1994-08-01), White
patent: 5830707 (1998-11-01), Bushman
patent: 5976795 (1999-11-01), Voytas et al.
patent: 6150511 (2000-11-01), Katz et al.
patent: 6228647 (2001-05-01), Voytas et al.
patent: 6720181 (2004-04-01), Chiaur et al.
patent: 2001/0043921 (2001-11-01), Gunzburg et al.
patent: 2003/0003567 (2003-01-01), Barber et al.
patent: 2003/0119023 (2003-06-01), Choo et al.
patent: 2004/0110923 (2004-06-01), Moore et al.
patent: WO 96/06166 (1996-02-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/53058 (1998-11-01), None
patent: WO 98/53060 (1998-11-01), None
patent: WO 99/07389 (1999-02-01), None
patent: WO 2004/009792 (2004-01-01), None
Saenz et al., FIV: from lentivirus to lentivector, 2004, The Journal of Gene Medicine, vol. 6, pp. S95-S104.
Priet et al., JBC Papers in Press. Published on Nov. 27, 2002 as Manuscript M209311200, 27 pages.
Dvorin et al., Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import, 2002, Journal of Virology, vol. 76, No. 23, pp. 12087-12096.
Van Maele et al., Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction, 2003, Journal of Virology, vol. 77, No. 8, pp. 4685-4694.
Whitwam et al., Identification of a Central DNA Flap in Feline Immunodeficiency Virus, 2001, Journal of Virology, vol. 75, No. 19, pp. 9407-9414.
Brooks et al., “Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors,”Proc. Natl. Acad. Sci. USA, 99: 6216-8221., 2002.
Bushman and Miller, “Tethering human immunodeficiency virus type 1 preintegration complexes to target DNA promotes integration at nearby sites,”J. Virol., 71: 458-464, 1997.
Bushman, “Integration site selection by lentiviruses: biology and possible control,”Current Topics in Microbiology&Immunology, 261: 165-77, 2002.
Bushman, “Tethering human immunodeficiency virus 1 integrase to a DNA site directs integration to nearby sequences,”Proc. Natl. Acad. Sci. USA, 91(20):9233-92337, 1994.
Bushman, “Targeting retroviral integration,”Science, 267(5203):1443-1444, 1995.
Busschots et al., “The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding,”J. Biol. Chem., 280:17841-7, 2005.
Cavazzana-Calvo et al., “Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease,”Science, 288: 669-72, 2000.
Ciuffi et al., “A role for LEDGF/p75 in targeting HIV DNA integration,”Nat. Med., 11:1287-9, 2005.
Derksen et al., “Feline immunodeficiency virus vectors. Gene transfer to mouse retina following intravitreal injection,”J. Gene Med., 4: 463-469., 2002.
Espanel and Sudol, “Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains,”J. Biol. Chem., 276:14514-14523, 2001.
Goulaouic and Chow, “Directed integration of viral DNA mediated by fusion proteins consisting of human immunodeficiency virus type 1 integrase andEscherichia coliLexA protein,”J. Virol., 70(1):37-46, 1996.
Hacein-Bey-Abina et al., “A Serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency,”N. Engl. J. Med., 348: 255-256., 2003.
Hacein-Bey-Abina et al., “LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1,”Science, 302: 415-19, 2003.
Haren et al., “Integrating DNA: transposases and retroviral integrases,”Annu. Rev. Microbio., 53:245-281, 1999.
Hughes et al., “Viral-mediated gene transfer to mouse primary neural progenitor cells,”Mol. Ther., 5: 16-24., 2002.
Joag et al.,Lentiviruses. In: Fields BN, Knipe DM, Howley PM (eds.) Fields Virology. Lippincott—Raven Publishers, Philadelphia, pp. 1977-1996, 1996.
Johnston et al., “Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors,”J. Virol., 73: 4991-5000, 1999.
Kang et al., “In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with ross river virus glycoproteins,”J. Virol., 76: 9378-9388, 2002.
Khan et al., “Retroviral integrase domains: DNA binding and the recognition of LTR sequences,”Nucl. Acids Res., 19: 851-60, 1990.
Kumar et al., “Large-scale production of pseudotyped lentiviral vectors using baculovirus GP64,”Hum. Gene Ther., 14: 67-77, 2003.
Kuriyan and Cowburn, “Modular peptide recognition domains in eukaryotic signaling,”Annu. Rev. Biophys. Biomol. Struct., 26:259-288, 1997.
Llano et al., “LEDGF/p75 determines celluar tranfficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes,”J. Virol., 78:9524-37, 2004.
Lotery et al., “Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors,”Hum. Gene Ther., 13: 689-696., 2002.
Mitchell et al., “Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences,”PLoS Biol2: E234, 2004.
Molteni et al., “Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain,”Acta Crystallographica Section D-Biological Crystallography. 57: 536-44, 2001.
Nourry et al., “PDZ domain proteins: plug and play!,”Sci. STKE. 179:RE7, 2003.
Olivares et al., “Site-specific genomic integration produces therapeutic factor IX levels in mice,”Nature Biotechnology, 20: 1124-28, 2002.
Ortiz-Urda et al., “Stable nonviral genetic correction of inherited human skin disease,”Nature Med8: 1166-70, 2002.
Otte et al., “WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains,”Protein Science, 12:491-500, 2003.
Polard and Chandler, “Bacterial transposases and retroviral integrases,”Mol. Microbiol., 1:13-23, 1995.
Quackenbush et al., “The TIGR gene indices: analysis of gene transcript sequences in highly sampled eukaryotic species,”Nucleic Acids Res., 29: 159-164., 2001.
Sandmeyer, “Integration by design,”Proc. Natl. Acad. Sci. USA, 100: 5586-88, 2003.
Schröder et al., “HIV-1 integration in the human genome favors active genes and local hotspots,”Cell, 110: 521-529., 2002.
Schuler, “Pieces of the puzzle: espressed sequence tags and the catalog of human genes,”J. Mol. Med., 75: 694-698., 1997.
Shibagaki and Chow, “Central Core Domain of Retroviral Integrase is responsible for target site selection,”J. Biol. Chem., 272:8361-8369.
Shibagaki et al., “Characterization of feline immunodeficicency virus integrase and analysis of functional domains,”Virology, 230: 1-10, 1997.
Sinn et al., “Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer,”J Virol., 79(20):12818-27, 2005.
Stein et al., “In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors,”Mol. Ther., 3: 850-856., 2001.
Tan et al., “Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites,”J. Virol., 78: 1301-13, 2004.
Vigdal et al., “Common physical properties o
Dai Junbiao
McCray, Jr. Paul B.
Sinn Patrick L.
Voytas Daniel F.
Blumel Benjamin P
Campell Bruce
Fulbright & Jaworski LLP
Iowa State University & Research Foundation, Inc.
University of Iowa Research Foundation
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