Compositions and methods of using apoptosis signaling kinase...

Details Compositions and methods of using apoptosis signaling kinase... Compositions and methods of using apoptosis signaling kinase...

2006-09-19

2006-09-19

Prouty, Rebecca A. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S194000, C435S320100, C435S325000, C435S069100, C536S023200

Reexamination Certificate

active

07109021

ABSTRACT:
The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.

REFERENCES:
patent: WO 01/77338 (2001-10-01), None
patent: WO 02/46384 (2002-06-01), None
Gotoh et al., “Reactive Oxygen Species- and Dimerization -Induced Activation of Apoptosis Signal-regulating Kinase 1 In Tumor Necrosis Factor-α Signal Transduction”,J. Biol. Chem, 1998, pp. 17477-17482, vol. 273.
Hatai et al., “Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-Induced Apoptosis by the Mitochondria-dependent Caspase Activation”,J. Biol. Chem, 2000, pp. 26576-26581, vol. 275.
Ichijo, et al., Induction of Apoptosis byASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways,Science, 1997, pp. 90-94, vol. 275.
Johnson et al., “Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases”,Science, 2002, pp. 1911-1912, vol. 298.
Kagi et al., “TNF Receptor 1-Dependent β Cell Toxicity as an Effector Pathway in Autoimmune Diabetes”,J Immunol, 1999, pp. 4598-4605, vol. 162.
Kaneto et al., “Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells”,Diabetes, 1995, pp. 733-738, vol. 44.
Kyriakis et al., “Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation”,Physiol Rev, 2001, pp. 807-869, vol. 81.
Liu et al., “Thioredoxin Promotes ASK1 Ubiquitination and Degradation to Inhibit ASK1-Mediated Apoptosis in a Redox Activity-Independent Manner”,Circ. Res, 2002, pp. 1259-1266, vol. 90.
Mandrup-Poulsen, et al., “Human Tumor Necrosis Factor Potentiates Human Interleukin 1-Mediated Rat Pancreatic β-Cell Cytotoxicity”,J Immunol, 1987, pp. 4077-4082, vol. 139.
Mathis et al., “β-Cell death during progression to diabetes”,Nature, 2001, pp. 792-798, vol. 434.
Nishitoh et al., “ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats”,Genes and Development, 2002, pp. 1345-1355, vol. 16.
Takeda et al., “Roles of MAPKKK ASK1 in Stress-Induced Cell Death”,Cell Structure and Function, 2003, pp. 23-29, vol. 28.
Tibbles et al., “The stress-activated protein kinase pathways”,Cell Mol. Life Sci., 1999, pp. 1230-1254, vol. 55.
Tobiume et al., “ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis”,EMBO Reports, 2001, pp. 222-228, vol. 2.
Tobiume et al., “Activation of Apoptosis Signal-Regulating Kinase 1 by the Stress-Induced Activating Phosphorylation of Pre-Formed Oligomer”,J Cell Physiology, 2002, pp. 95-104, vol. 191.
Tournier et al., “Requirement of JNK for Stress-Induced Activation of the Cytochrome c-Mediated Death Pathway”,Science2000, pp. 870-874, vol. 288.
Zhou et al., “Apoptosis in Insulin-secreting Cells”,J Clin. Invest., 1998, pp. 1623-1632, vol. 101.

Affiliated with

Also associated with

Rating

Compositions and methods of using apoptosis signaling kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods of using apoptosis signaling kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of using apoptosis signaling kinase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3561633