Compositions and methods of treatment of sympathetically maintai

Details Compositions and methods of treatment of sympathetically maintai Compositions and methods of treatment of sympathetically maintai

1992-06-25

1995-09-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424449, A61K 31415

Patent

active

054479479

ABSTRACT:
Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an .alpha.-adrenergic antagonist, .alpha.-1-adrenergic antagonist, .alpha.2 adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine. Examples demonstrate relief of pain by application of phentolamine or clonidine.

REFERENCES:
patent: 4201211 (1990-05-01), Chandrasekaran et al.
patent: 4250191 (1981-02-01), Edwards
patent: 4310535 (1982-01-01), Pierpaoli
patent: 4443441 (1984-04-01), Galin
patent: 4742054 (1988-05-01), Naftchi
patent: 4801587 (1989-01-01), Voss et al.
Raynayd's Phenomenon and Disease Merck Manual Holvey, Ed. 1972, p. 487.
CA 108:124399 Nakamura et al in Eur, J. Pharmacol (1988) 146 (2-3), 223-8.
CA:107:51700 Ito et al. in Jpn. J. Pharmacol. (1987) 44 (2) 121-6.
Curtis and Marwah, "Evidence for Alpha Andrenoceptor Modulation of the Nociceptive Jaw-Opening Reflex in Rats and Rabbits" J. Pharmacology Experimental Therapeutics 238, 576-579 (Aug. 1988).
Sagen and Proudfit, "Evidence for Pain Modulation by Pre- and Postsynaptic Noradrenergic Receptors in the Medulla Oblongate" Brain Research 331, 285-293 (1985).
M. Ishizuki, Letter to the Editor, "Clinical Application of Guanethidine Ointment to the Treatment of Painful States and Allodynia" Clinical Journal of Pain 261 (1988).
Janig, W., Trends in NeuroSciences 8(11), 471-77 (1985).
Loh, L., et al., J. Neurol. Neurosurg. Psychiat. 41(7), 664-71 (1978).
Naftchi, N., Chem. Abst. 110(9):69410r.
Nakagawa, et al., Chem. Abstr. 111(2):12526z.
Nakagawa, et al., Chem. Abstr. 110(12):101838z.
Gonzales, et al., J. Neurochem. 53(5), 1595-98 (1989).
Hobelmann, et al., Microsurg. 10(2), 151-53 (1989).
Price, et al. Pain 36(3), 273-88 (1989).

Affiliated with

Also associated with

Rating

Compositions and methods of treatment of sympathetically maintai does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods of treatment of sympathetically maintai, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of treatment of sympathetically maintai will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-473004