Compositions and methods of treatment of sympathetically...

Drug – bio-affecting and body treating compositions – Anesthetic – topical

Reissue Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S252120, C514S253040, C514S310000, C514S354000, C514S410000, C514S462000, C514S634000, C514S643000, C514S651000, C514S654000

Reissue Patent

active

RE041998

ABSTRACT:
Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

REFERENCES:
patent: 4201211 (1980-05-01), Chandrasekaran et al.
patent: 4250191 (1981-02-01), Edwards
patent: 4310535 (1982-01-01), Pierpaoli
patent: 4443441 (1984-04-01), Galin
patent: 4557934 (1985-12-01), Cooper
patent: 4742054 (1988-05-01), Naftchi
patent: 4746509 (1988-05-01), Haggiage et al.
patent: 4801587 (1989-01-01), Voss et al.
patent: 5070084 (1991-12-01), Campbell
patent: 5447947 (1995-09-01), Campbell
patent: 6054461 (2000-04-01), Fairbanks et al.
patent: 6147102 (2000-11-01), Borgman
patent: 6534048 (2003-03-01), Borgman
patent: 6559186 (2003-05-01), Campbell
patent: 2004/0101582 (2004-05-01), Wolicki
patent: 2004/0132824 (2004-07-01), Gil et al.
patent: 2920500 (1980-11-01), None
patent: 0 241 050 (1987-10-01), None
patent: 1 216 928 (1989-08-01), None
patent: WO 92/14453 (1992-09-01), None
patent: WO 2007/025613 (2007-03-01), None
Indoramin: http://www.netdoctor.co.uk/medicines/100000841.html. [online] retrieved from the internet on Dec. 11, 2008; Jun. 11, 2007; 5 pages.
Labetalol: http://www.answers.com/labetalol; [online] retrieved from the internet on Dec. 11, 2008; Jul. 1, 2002; 7 pages.
Phenoxybenzamine: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682059.html; [online] retrieved from the internet on Dec. 11, 2008; Apr. 1, 2003; 3 pages.
Medetomidine: http://www.answers.com/topic/medetomidine-1; [online] retrieved from the internet on Dec. 11, 2008; 4 pages.
Reserpine: http://www.answers.com/topic/reserpine; [online] retrieved from the internet on Dec. 11, 2008; Jul. 1, 2002; 9 pages.
Ergoloid mesylates: http://web.archive.org/web/20071018155031/http:/umm.edu/altmed/drugs/ergoloid-mesylates-048700.htm; [online] retrieved from the internet on Dec. 15, 2008; Oct. 18, 2007; 6 pages.
Clonidine: http://www.answers.com/topic/clonidine; [online] retrieved from the internet on Dec. 12, 2008; Jul. 1, 2002; 8 pages.
Bretylium tosylate: http://www.medicinenet.com/bretylium_tosylate-injection/article.htm; [online] retrieved from the internet on Dec. 12, 2008; Mar. 2, 2005; 2 pages.
Captopril; http://www.answers.com/topic/captopril; [online] retrieved from the internet on Dec. 11, 2008; 9 pages.
Phentolamine; http://www.answers.com/topic/phentolamine; [online] retrieved from the internet on Dec. 11, 2008; Jul. 1, 2002; 7 pages.
Prazosin; http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682245.html; [online] retrieved from the internet on Dec. 11, 2008; Mar. 1, 2007; 3 pages.
Guanfacine: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682245.html; [online] retrieved from the internet on Dec. 11, 2008; Jul. 1, 2002; 6 pages.
Nitroglycerin ointment: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682346.html; [online] retrieved from the internet on Dec. 11, 2008; Apr. 1, 2003; 3 pages.
Nicergoline; http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682346.html; [online] retrieved from the internet on Dec. 11, 2008; 4 pages.
Rauwolfia: http://www.answers.com/topic/rauwolfia; [online] retrieved from the internet on Dec. 11, 2008; 4 pages.
Engelman. Hypertension, 1988, 11(suppl II), II-30-II-33).
Nefazodone: http://www.answers.com/topic/labetalol; [online] retrieved from the internet on Dec. 11, 2008; Oct. 25, 2004; 8 pages.
Trazodone: http://www.answers.com/topic/trazodone; [online] retrieved from the internet on Dec. 11, 2008; Jul. 1, 2002; 13 pages.
Alfuzosin: http://www.answers.com/topic/alfuzosin; [online] retrieved from the internet on Dec. 11, 2008; Jun. 25, 2003; 4 pages.
Guanadrel: http://www.medicinenet.com/guanadrel-oral/article.htm; [online] retrieved from the internet on Dec. 12, 2008; Mar. 2, 2005; 2 pages.
Harich Comparative Pain Scale http://www.tipna.org/info/documents/ComparativePainScale.htm [online] retrieved from the internet on Dec. 12, 2008; Jul. 2002 4 pages.
Byas-Smith, et al., “Transdermal clonidine compared to placebo in painful diabetic neuropathy using a two-stage ‘enriched enrollment’ design”,Pain, 60(3):267-74 (1995).
Jarrott, et al., “Clonidine: understanding its disposition, sited and mechanism of action”,Clin. Exp. Pharmacol. Physiol.,14(5):471-9 (1987).
Peltier and Russell, “Recent advances in drug-induced neuropathies”,Curr. Opin. Nerology,15:633-638 (2002).
Singleton, “Evaluation and treatment of painful peripheral polyneuropathy”,Semin. Neurol.,25(2): 185-95 (2005).
Zeigler, et al., “Transdermal clonidine versus placebo in painful diabetic neuropathy”,Pain, 48(3):403-8 (1992).
Abram, et al., “Treatment of long-standing causalgia with prazosin”Regional Anesthesia6(2):79-81 (1981).
Berkow,The Merck Manual of Diagnosis and Therapy,15thEdition,pp. 1347-1349, Merch & Co.: Rahway, N.J., 1987.
Curtis and Marwah, “Evidence for alpha adrenoceptor modulation of the nociceptive jaw-opening reflex in rats and rabbits”J. Pharmacology Experimental Therapeutics238:576-579 (1988).
Davis, et al., “Topical application of clonidine relieves heperalgesia in patients with sympathetically maintained pain”Pain47(3):309-317 (1991).
De Oliveira, et al., “Pain reaction after topical NA and lesions of the obex region in the alert guinea pig”Physiology&Behavior28(3):413-416 (1982).
Ghostine, et al., “Phenoxybenzamine in the treatment of causalgia”Journal of Neurosurgery60(6):1263-1268 (1984).
Goodman, et al.,The Pharmacological Basis of Therapeutics(6thEdition) Chapter, 9, pp. 176-210, MacMillan: New York, 1980.
Gonzales, et al., “Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons”J. Neurochem.53(5):1595-1598 (1989).
Hobelman, et al., “Use of prolonged sympathetic blockage as an adjunct to surgery in the patient with sympathetic maintained pain”Microsurg.10(2):151-153 (1989).
Index Nominum 1987pp. 284, Swiss Pharmaceutical Society: Zurich, CH, 1987.
Ishizuki, “Clinical application of guanethidine ointment to the treatment of painful states and allodynia”Clinical Journal of Pain261 1988.
Ito, et al., “Effects of calcium antagonists on alpha-adrenoceptor mediated vasoconstrictions of the canine intermediate auricular artery”Jpn. J. Pharmacol.44(2):121-126 (1987).
Janig, “Causalgia and reflex sympathetic dystrophy: in which way is the sympathetic nervous system involved?”Trends in Neurosciences8(11):471-477 (1985).
Krieglstein, “The influence of topically applied bethanidine on intraocular pressure and pupil in the rabbit”Graefes ARchiv. Ophthalmologie196(1):31-38 (1975).
Krieglstein, “The influence of bretylium tosylate on the intraocular pressure of the rabbit”Graefes Archiv. Ophthalmologie197(2):153-158 (1975).
Loh and Nathan, “Painful peripheral states and sympathetic blocks”J. Neurol. Neurosurg. Psychiat.41(7):664-671 (1978).
Merck Manual, Raynard's Phenomenon And Disease, Holvey, Ed. pp. 487 1972.
Naftchi,Chem. Abstr.110(9):69410r (1980).
Nakagawa, et al.,Chem. Abstr.111(1):12526z (1989).
Nakagawa, et al.,Chem. Abstr.110(11):101838z (1989).
Nakamura, et al., “Peripheral analgesic action of clondine: mediation by release of endogenous enkephalin-like substances”Eur. J. Pharmacol.146(2-3), 223-228 (1988).
Nakamura, et al., “Peripheral modulation of pain in conscious guinea pigs: effect of morphine, nalorphine and clonidine”Brazilian Journal of Medical and Biological Research21(3):577-583 (1988).
Olin, et al.,Facts and Comparisonspp. 162e, J.B. Lipincott Co.: St. Louis, Mo., 1988.
Price, et al., “Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block”Pain36(3):273-288 (1989).
Sagen and Proudfit,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods of treatment of sympathetically... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods of treatment of sympathetically..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of treatment of sympathetically... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4189247

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.