Compositions and methods of treating HIV with d4T, 5-fluorouraci

Details Compositions and methods of treating HIV with d4T, 5-fluorouraci Compositions and methods of treating HIV with d4T, 5-fluorouraci

1996-06-27

1998-02-17

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514274, 536 2855, 544309, 544310, 544313, C07H 19073, A01N 4354, A61K 31505, A61K 3170

Patent

active

057191328

ABSTRACT:
The present invention is directed to the use of pharmaceutical compositions containing anti-retroviral effective amounts of (a) d4T and (b) 5-fluorouracil or a prodrug, or salt thereof.

REFERENCES:
patent: 3948897 (1976-04-01), Townsend et al.
patent: 4328229 (1982-05-01), Fujii et al.
patent: 4507301 (1985-03-01), Fujii et al.
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4861759 (1989-08-01), Mitsuya et al.
patent: 4863902 (1989-09-01), Amagase et al.
patent: 4978655 (1990-12-01), Lin et al.
patent: 5116823 (1992-05-01), Calabresi et al.
patent: 5521161 (1996-05-01), Malley et al.
patent: 5525603 (1996-06-01), Shirasaka et al.
patent: 5530003 (1996-06-01), Yanagawa
patent: 5534513 (1996-07-01), Junji et al.
S.D. Malley, et al, "Suppression of HIV Production in Resting Lymphocytes by Combining Didanosine and Hydroxamate Compounds," The Lancet, vol. 343, p. 1292, May 21, 1994.
M.R. Posner, et al, "High-Dose Intravenous Zidovudine with 5-Fluorouracil and Leucovorin," Cancer, vol. 70, No. 12, pp. 2929-2934, Dec. 15, 1992.
S.A. Riddler, et al, "Antiretroviral Activity of Stavudine (2',3'-Didehydro-3'-Deoxythymidine, D4T)," Antiviral Research, vol. 27, pp. 189-203, 1995.
P.F. Lin, et al, "Genotypic and Phenotypic Analysis of Human Immunodeficiency Virus Type 1 Isolates from Patients on Prolonged Stavudine Therapy," J. Infect. Dis., vol. 170, pp. 1157-1164, 1994. (November).
W.-Y. Gao, et al, "Anti-Human Immunodeficiency Virus Type 1 Activity of Hydroxyurea in Combination with 2',3'-Dideoxynucleosides," Mol. Pharm., vol. 46, pp. 767-772, 1994.
F. Lori, et al, "Hydroxyurea as an Inhibitor of Human Immunodeficiency Virus-Type 1 Replication," Science, vol. 266, pp. 801-805, (Nov. 4, 1994).
V.A. Johnson and R.E. Byington, "Quantitative Assays for Virus Infectivity," in A. Aldovini and B.D. Walker (Ed.), Techniques in HIV Research, Stockton Press, New York, pp. 71-76, 1990.
S, Cox, et al, "Comparison of the Intracellular Metabolism of 3'-Azido-3'-Deoxythymidine and 3'-Fluoro-3'-Deoxythymidine in Lymphocytes in the Presence of 5-Fluoro-2'-Deoxyuridine," Antiviral Chemistry and Chemotherapy, vol. 1, No. 2, pp. 155-161, 1990.
W.-Y. Gao, et al, "Low Levels of Deoxynucelotides in Peripheral Blood Lymphocytes: A Strategy to Inhibit Human Immunodeficiency Virus Type 1 Replication," Proc. Natl. Acad. Sci., vol. 90, pp. 8925-8928, Oct., 1993.
J. Balzarini, et al, "2',3'-Dideoxycytidine: Regulation of its Metabolism and Anti-Retroviral Potency by Natural Pyrimidine Nucleogide Synthesis, and by Inhibitors of Pyrimidine Nucleotide Synthesis " Molecular Pharmacology, vol. 32, No. 6, pp. 798-806, Dec., 1987.
M.N. Prichard, et al, "Inhibition of Thymidylate Synthase and Dihydrofolate Reductase Potentiate the Antiviral Effect of Acyclovir," Antiviral Research, vol. 20, pp. 249-259, 1993.
F. Lori, et al, "Hydroxyurea Inhibits HIV-1 Replication by Inducing Low dNTP Levels. A Cellular Enzyme as a Target to Inhibit HIV-1," Antiviral Research, vol. 23, p. 63, 1994.
W.-Y. Gao, et al, "Anti-HIV 1 Activity of Hydroxyurea in Combination with 2',3'-Dideoxynucleosides," Clinical Research, vol. 42, No. 2, p. 280A, 1994.
Gong et al., "Potentiation of the Stavudine Anti-Human Immunodeficiency Virus Activity by 5-Fluorouracil," Antimicrobial Agents & Chemotherapy, 40(5), 1229 (May 1996).
Vila et al, "Absence of Viral Rebound After Treatment of HIV-Infected Lancet,350(9078), 635-636 (Aug. 30, 1997).

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