Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2010-05-03
2011-12-27
Schnizer, Richard (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S024500, C600S001000, C378S065000
Reexamination Certificate
active
08084438
ABSTRACT:
The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and methods of SPK inhibitors, including siRNAs, which specifically block gene expression of SPK and potentiates the effect of radiation in the treatment of various cancers.
REFERENCES:
patent: 2004/0171037 (2004-09-01), Li et al.
GenBank Accession BC011432 (Nov. 19, 2003).
Samsel et al (The Prostate 58: 382-393, 2004).
Validation of an anti-sphingosine-1 phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages (Cancer Cell 2006;9:225-38) by Barbara Visentin, et al.
Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases (Mole) (Cell. Bio 2002;22:77587768) by Xiaodong Shu, et al.
Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models (Cancer Res. 2005;65:11667-75) by Dimitri Pchejetski, et al.
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. (FASEB J. 2006; 20:386-8) by Toshihiko Kawamori, et al.
Discovery and Evaluation of Inhibitors of Human Sphingosine Kinase. (Cancer Res. 2003;63;5962-9) by Kevin J. French,et al.
N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide (Biochemistry. 1998;37:12892-8) by Lisa C. Edsall, et al.
Sphingosine Enhances Apoptosis of Radiation-resistant Prostate Cancer Cells (Cancer Res. 2000 Aug. 15;60 (16):4468-74) by Victor E. Nava, et al.
PCT International Search Report mailed Sep. 10, 2008 based on PCT/US2007/086057.
Masood Rizwan
Sinha Uttam K.
DLA Piper (LLP) US
Schnizer Richard
University of Southern California
LandOfFree
Compositions and methods of sphingosine kinase inhibitors in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods of sphingosine kinase inhibitors in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of sphingosine kinase inhibitors in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4297374