Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-07-31
2008-12-30
Marschel, Ardin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S274000, C514S459000, C514S721000
Reexamination Certificate
active
07470672
ABSTRACT:
This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. There orotate derivatives are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthrracyclines.
REFERENCES:
Theodoulou, et al.; “Cardiac Profiles of Liposomal Anthracyclines: Greater Safety versus Conventional Doxorubicin?”; 2004; Cancer; 100 (10): 2052-2063.
Rosenfeldt; “Editorial: Metabolic Supplementation with Orotic Acid and Magnesium Orotate”; 1998; Cardiovasc. Drugs Ther.; 12: 147-152.
Karmali, Esq. Rashida A.
Marschel Ardin
Savvipharm Inc.
Thomas Timothy P
LandOfFree
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