Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2006-08-09
2010-02-16
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S085200
Reexamination Certificate
active
07662405
ABSTRACT:
This invention provides methods and compositions for localized delivery of IL-12 to a desired site. The composition comprises liposomes carrying IL-12. The liposomes comprise phosphatidyl choline, phosphatidyl glycerol and cholesterol. The size and composition of the liposomes is such that there is minimal leakage into the systemic circulation. These compositions can be used for delivery of IL-12 to selected sites such as tumors.
REFERENCES:
patent: 4127502 (1978-11-01), Li Mutti et al.
patent: 4795806 (1989-01-01), Brown et al.
patent: 5580856 (1996-12-01), Prestrelski et al.
patent: 5908620 (1999-06-01), Tu et al.
patent: 6033708 (2000-03-01), Kwasiborski et al.
patent: 6423308 (2002-07-01), Yarchoan et al.
patent: 6544549 (2003-04-01), Boni et al.
patent: 6593294 (2003-07-01), Baru et al.
patent: 6787132 (2004-09-01), Gabizon et al.
patent: 2001/0043914 (2001-11-01), Mathiowitz et al.
patent: 2002/0098192 (2002-07-01), Whitlow et al.
patent: 2002/0132982 (2002-09-01), Balasubramanian et al.
patent: 2003/0118539 (2003-06-01), Fahl et al.
patent: 2003/0176331 (2003-09-01), Rosenblum et al.
patent: 2004/0229793 (2004-11-01), Balasubramanian et al.
patent: 2004/0247661 (2004-12-01), Michaeli et al.
patent: 2005/0136034 (2005-06-01), Chen et al.
patent: 2007/0053918 (2007-03-01), Panzner et al.
patent: WO99/55306 (1999-11-01), None
Gabizon et al., Liposome formulations with prolonged circulation time in blood and enhanced uptake in tumors. Proc. Natl. Acad. Sci., USA, 85, 6949-6953, 1988.
Kirby, et. al.,Preparation of liposomes containing factor VIII for oral treatment of haemophilia. Journal of Microencapsulation, Jan. 1984, vol. 1, pp. 33-45.
Aguilar, et. al.,Phospholipid membranes form specific nonbilayer molecular arrangements that are antigenic, Sep. 1999, Journal of Biological Chemistry, vol. 274, No. 36, pp. 25193-25196.
Manning, et al.,Stability of Protein Pharmaceuticals; Pharmaceutical Research, vol. 6, No. 11, 1989, pp. 903-918.
Balasubramanian, et al.,Liposomes as Formulation Excipients for Protein Pharmaceuticals: A Model Protein Study; Pharmaceutical Research, vol. 17, No. 3, 2000, pp. 344-350.
Braun, et al.,Protein Aggregates Seem to Play a Key Role Among the Parameters Influencing the Antigenicity of Interferon Alpha(IFN-α)in Normal and Transgenic Mice; Pharmaceutical Research, vol. 14, No. 10, 1997, pp. 1472-1478.
Lenting, P.J., et al.,The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein; The Journal of Biological Chemistry, Aug. 1999, vol. 274, No. 34, pp. 23734-23739.
Raut, et al.,Phospholipid binding of factor VIII in different therapeutic concentrates; British Journal of Hematology, 1999, vol. 107, pp. 323-329.
Balu-Iyer Sathy V.
Bankert Richard B.
Purohit Vivek S.
Hodgson & Russ LLP
Spector Lorraine
Stoica Elly-Gerald
The Research Foundation of State University of New York
LandOfFree
Compositions and methods of preparation of liposomal... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods of preparation of liposomal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of preparation of liposomal... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4226373