Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1987-06-08
1989-09-05
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424439, A61K 968
Patent
active
048637378
ABSTRACT:
Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder. Employing the present invention, the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy " matrix. The pH and pKa of the powder matrix can be modified to increase the absorption of the drug through the mucosal tissues.
REFERENCES:
patent: D93287 (1934-09-01), Reed
patent: 109677 (1870-11-01), Seitz
patent: D117455 (1939-11-01), Parr
patent: D117456 (1939-11-01), Parr
patent: 1430642 (1922-10-01), Gross
patent: 1593858 (1926-07-01), Venable
patent: 1847415 (1932-03-01), Snell
patent: 1915614 (1933-06-01), Parker
patent: 1971560 (1934-08-01), Guyon
patent: 2096611 (1937-10-01), Ellestad
patent: 2208120 (1940-07-01), Coleman
patent: 2246778 (1941-06-01), Cahoon
patent: 2295042 (1942-09-01), Llewellyn
patent: 2323656 (1943-07-01), Helfenstein
patent: 2388533 (1945-11-01), Edmondson et al.
patent: 2469589 (1949-05-01), Barricini
patent: 2488272 (1949-11-01), Davis
patent: 2499734 (1950-03-01), Edmondson et al.
patent: 2508560 (1950-05-01), Adams
patent: 2553446 (1951-05-01), Edmondson et al.
patent: 2857908 (1958-10-01), Cornfield
patent: 2897624 (1959-08-01), Yakel et al.
patent: 2915061 (1959-12-01), Edmondson et al.
patent: 2926121 (1960-02-01), Hobbs et al.
patent: 2963404 (1960-12-01), Hammer et al.
patent: 3169907 (1965-02-01), Heusser et al.
patent: 3172179 (1965-03-01), Schafer
patent: 3192924 (1965-07-01), Edmondson et al.
patent: 3210247 (1965-10-01), Suranyi
patent: 3264115 (1966-08-01), Davis
patent: 3271256 (1966-09-01), Frey
patent: 3341414 (1967-09-01), Cherkas et al.
patent: 3344030 (1967-09-01), Stevens et al.
patent: 3399673 (1968-09-01), Jones et al.
patent: 3418743 (1968-12-01), Halvorsen
patent: 3429308 (1969-02-01), Russell
patent: 3493652 (1970-02-01), Hartman
patent: 3556811 (1971-01-01), Smith
patent: 3797494 (1974-03-01), Zaffaroni
patent: 3816953 (1974-06-01), Hameen-Anttila
patent: 3867927 (1975-02-01), Hergott
patent: 3943928 (1976-03-01), Lariccia et al.
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4060084 (1977-11-01), Chandrasekaran et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4139627 (1979-02-01), Lane et al.
patent: 4168308 (1979-09-01), Wretlind et al.
patent: 4169885 (1979-10-01), Raaf et al.
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4307075 (1981-12-01), Martin
patent: 4346709 (1982-08-01), Schmitt
patent: 4372942 (1983-02-01), Cimiluca
patent: 4390520 (1983-06-01), Nagai et al.
patent: 4466953 (1984-08-01), Keith et al.
patent: 4470962 (1984-09-01), Keith et al.
patent: 4482534 (1984-11-01), Blank
patent: 4485087 (1984-11-01), Otsuka et al.
patent: 4517173 (1985-05-01), Kizawa et al.
patent: 4529589 (1985-07-01), Davydov et al.
patent: 4551329 (1985-11-01), Harris et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4588580 (1986-05-01), Gale et al.
patent: 4671953 (1987-06-01), Stanley et al.
Dyer, "Medicated Candies" Q.S. 4 (1953).
Brown, "Absorption of Analgesics from the Buccal Mucous Membrane", 196 The Practitioner, 125 (1966).
Beckett et al., "Buccal Absorption of Basic Drugs and its Application as an In Vivo Model of Passive Drug Transfer through Lipid Membrands," 19 J. Pharm. Pharmac. 31S (1967).
Dearden et al., "Buccal Absorption as a Parameter of Analgesic Activity of Some P-Substituted Acetanilides," 23 Journal Pharm. Pharmac. 73S (1971).
Dearden et al., "A New Buccal Absorption Model," 23 J. Pharm. Pharmac. 68S (1971).
Dollery et al., "Differences in the Metabolism of Drugs Depending Upon Their Routes of Administration," 179 Annals of te New York Academy of Sciences 108 (1971).
Dobkin, "Buprenorphine Hydrochloride: Determination of Anaglesic Potency," 24 Canadian Anaesthesiology Society Journal 186 (1977).
Edge et al., "Analgesic Effects of Sublingual Buprenorphine," 34 Anaesthesia 463 (1979).
Fry, "Relief of Pain After Surgery," 34 Anaesthesia 549 (1979).
Bullingham et al., "Sublingual Buprenorphine Used Postoperatively: Clinical Observations and Preliminary Pharmacokinetic Analysis," 12 Br. J. Clin. Pharmac. 117 (1981).
Hug et al., "The Pharmacokinetics of Fentanyl," Janssen Pharmaceutica Inc. (1981).
Ellis et al., "Pain Relief After Abdominal Surgery-A Comparison of I.M. Morphine, Sublingual Buprenorphine and Self-Administered I.V. Pethidine," 54 Br. J. Anaesth. 421 (1982).
Port et al., "Carfentanil: The Primate Experience," American College of Veterinary Anesthesiologist (1983).
Port et al, "Topical Narcotic Anesthesia," 59 Anesthesiology (1983).
Windholz et al., "The Merck Index," published by Merck & Co., Inc., pp. 575, 795, 796, and Appendix 3 (1983).
Abrams, "New Nitrate Delivery Systems: Buccal Nitroglycerin", vol. 105 American Heart Journal, pp. 848-854 (May 1983).
White et al., "Comparative Pharmacology of Intravenous Anesthetics-A Model for Determining Dosage Requirements and Therapeutic Concentration Ranges During Surgery," 59 Anesthesiology, A379 (Sep. 1983).
Asthana et al., "Verapamil Disposition and Effect on PQ-Intervals After Buccal, Oral and Intravenous Administration," Arzneim.-Forsch./Drug Res., pp. 498-502 (1984).
Derbyshire et al., "Non-Parenteral Postoperative Analgesia," Anesthesia 39, pp. 324-328 (1984).
DeBoer et al., "Drug Absorption by Sublingual and Rectal Routes," 56 British Journal of Anaesthesiology 69 (1984).
Stanley et al., "The Effect of Population Habits on Side Effects and Narcotic Requirements During High-Dose Fentanyl Anaesthesia," 31 Can Anaesth Soc. J. 398 (1984).
Bailey et al., "Anesthetic Induction with Fentanyl," 64 Anesth Analg 48 (1985).
Stanley et al., "Management of Pain and Pain-Related Problems in the Critically I11 Patient," in Critical Care, State of the Art, vol. 6 (1985).
Huttel et al., "Sublingual Flunitrazepam for Premedication," Acta Anaesthesiol Scand. 29, pp. 209-211 (1985).
Risbo et al., "Sublingual Buprenorphine for Premedication and Postoperative Pain Relief in Orthopedic Surgery," Acta Anaesthesiol Scand. 29, pp. 180-182 (1985).
Bell et al., "Buccal Morphine--A New Route for Analgesia?" The Lancet 71 (1985).
Berry, "Premedication and Induction of the Difficult Child" (n.d.).
John F. Ryan, "Premedication, Induction and Parents," Newsletter Boston, Massachusetts (n.d.).
"Sublimize (Fentanyl) as the Citrate Injection: Product Information" (n.d.).
Stanley, "Computer Control of Intravenous Anesthesia," 423.
Schechter et al., "Status of Pediatric Pain Control: A Comparison of Hospital Analgesic Usage in Children and Adults," 77 Pediatrics 11 (1986).
Prys-Roberts et al., "Pharmacokinetics of Anaesthesia," Preface.
Bailey et al., "Pharmacology of Intravenous Narcotic Anesthetics," in Anesthesia 2nd ed. (Miller ed. 1986).
Su, "Intranasal Delivery of Peptides and Proteins," Pharmacy International (Jan. 1986).
Rothschild, "Are Sick Kids Treated Properly for Pain?", USA Today, Jan. 28, 1986.
Forbes et al., "2% Rectal Methohexital for Induction of Anesthesia in Children," vol. 65 Anesthesiology No. 3, (Sep. 1986).
Newspaper Article Entitled "Insulin Shots May Soon be Replaced by a Nasal Spray," Friday, Sep. 26, 1986, (UPI).
"New Drugs/Drug News", Hospital Therapy, pp. 9, 10, and 15 (Nov. 1986).
Davis, "Parenteral Therapy Techniques-Abstracts", Hospita
Hague Brian
Stanley Theodore H.
Page Thurman K.
University of Utah
LandOfFree
Compositions and methods of manufacture of compressed powder med does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods of manufacture of compressed powder med, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods of manufacture of compressed powder med will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-242434