Compositions and methods of making a photoactive agent

Details Compositions and methods of making a photoactive agent Compositions and methods of making a photoactive agent

2010-11-01

2011-11-22

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08063203

ABSTRACT:
An improved two stage reaction process for production of mono-L-aspartyl chlorin e6. In a first stage, the activation reaction between chlorin e6and a carbodiimide produces a previously unknown anhydride in an activation reaction product. This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e6. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.

REFERENCES:
patent: 0 200 218 (1986-11-01), None
patent: 0 629 409 (1994-12-01), None
Hargus, Jodie Angela, “Naturally-Derived Porphyrin and Chlorin Photosensitizers for Photodynamic Therapy,” master's thesis, Louisiana State University, 2005, 80 pages.
Hargus et al., “Mono-(L)-aspartylchlorin-c6,”Photochemistry and Photobiology 83:1-10, 2007.

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