Compositions and methods of inhibiting bacterial spore...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S252300, C435S173300, C435S007100, C530S350000, C530S300000, C530S324000

Reexamination Certificate

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06953683

ABSTRACT:
The present invention is directed to compositions comprising nisin and sublancin in amounts that are effective to inhibit bacterial spore germination. Additionally, the present invention is directed towards methods of inhibiting bacterial spore germination for a variety of purposes.

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U.S. Appl. No. 60/215,449, filed Jun. 29, 2000, Hansen.
Hansen, “Nisin and Related Antimicrobial Peptides”, Biotechnology of Antibiotics, Second Edition, Revised and Expanded, pp. 437-467.
Paik, S.H., et al. Isolation and Characterization of Chemical, Physical, and Biological Properti s of Sublancin 168, a Novel Lantibiotic; and the Cloning and Sequencing of the Structural G n of Sublancin 168 and its Transporter Protein. Dissertation Abstracts International. Jan. 1997, vol. 58, 11B, p. 5800.
Chakicherla, et al., “Role of the Leader and Structural Regions of Prelantibiotic Peptides as Assessed by Expressing Nisin-Subtiliin Chim ras in Bacillus subtilis 168, and Characterizati n of Their Physical, Chemical, and Antimicrobial Properties”, Journal f Biol. Chemistry, Oct. 1995, vol. 270, No. 40, pp. 23533-23539.

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