Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Nitrogen heterocycle
Patent
1994-02-23
1996-03-05
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Nitrogen heterocycle
424 7838, 514885, A61K 31765, A61K 31785
Patent
active
054965462
ABSTRACT:
Novel polyadenylic acid (5') derivatives with 2'-0-(3-fluoro-4,6-dinitrophenyl) groups and/or 2'-0-(2,4-dinitrophenyl) groups have been synthesized and discovered to act as mutation-insensitive and function-specific inhibitors of viral reverse transcriptase. The compositions, preparative procedures and methods of application of these novel compounds for the treatment of humans carrying or infected with AIDS virus and other RNA-viruses, of other mammals carrying RNA-viruses, for the fast but temporary protection of uninfected humans and other mammals against immuno-deficiency viruses and other RNA-virus caused diseases, for the preparation of a formulation containing irreversibly sterilized HIV or other RNA-viruses useful as anti-AIDS and anti-other RNA-virus disease vaccines, for the complete sterilization of possible trace amounts of live HIV and other RNA-viruses in stored transfusion blood, and for the inactivation or removal of trace amounts of ribonuclease in solution and containers used in biotechnology processes have all been disclosed.
REFERENCES:
Chuan et al Journal of Biological Chem. vol. 263, No. 26 pp. 13003-13006.
Chem. Ab. 77:1242G Steward et al.
Kang Insug
Rahman Mohammed H.
Wang Jui H.
Kulkosky Peter F.
Wang Jui H.
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