Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-09-05
2006-09-05
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C435S007100, C435S243000, C435S252300, C514S002600, C514S012200, C536S023700, C424S009100
Reexamination Certificate
active
07101969
ABSTRACT:
This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of aStaphylococcus aureus(S. aureus) DnaI related protein, as well as its variants. The invention also relates to a specific interaction between theS. aureusDnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by theS. aureusbacteriophage 77 genome. The phage open reading frame (ORF) product interacts with amino acids 150–313 ofS. aureusDnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. Accordingly, the invention provides a method for the inhibition of bacterial growth, and the treatment of bacterial infection via the inhibition of DnaI.
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DuBow Mike
Gros Philippe
Pelletier Jerry
Kam Chih-Min
Palmer & Dodge LLP
Targanta Therapeutics
Weber Jon
Williams Kathleen M.
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