Compositions and methods for WT1 specific immunotherapy

Details Compositions and methods for WT1 specific immunotherapy Compositions and methods for WT1 specific immunotherapy

2006-12-05

2006-12-05

Schwadron, Ronald B. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

C424S184100, C424S185100, C424S192100, C424S193100, C514S002600, C514S012200, C514S885000, C530S358000, C530S350000, C530S806000

Reexamination Certificate

active

07144581

ABSTRACT:
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

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