Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2009-08-17
2011-12-27
Belyavskyi, Michail (Department: 1644)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S130100, C424S577000
Reexamination Certificate
active
08084057
ABSTRACT:
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked α-gal epitopes for induction of recruitment of macrophages localized within or surrounding damaged tissue. The recruited macrophages and stem cells promote the repair and regeneration of the treated injured tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects. In some embodiments, the present invention provides treatments for injured tissues such as brain, peripheral nerve, muscle, cartilage, bone, gastrointestinal tract and dysfunctional endocrine tissues.
REFERENCES:
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patent: 2010/0226965 (2010-09-01), Galili
Feldman et al .Transplant. Proc. 1998, 30, 4126-4127.
Cochlovius et al .,( Modern Drug Discovery, 2003, pp. 33-38.
Galili et al ., Burns, 2010, v.36, p. 239-251.
LaTemple et al Cancer Research, 1999, v.59, pp. 3417-3423).
Belyavskyi Michail
Medlen & Carroll LLP
University of Massachusetts
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