Compositions and methods for vaccinating against HSV-2

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C435S006120, C435S091100

Reexamination Certificate

active

07935352

ABSTRACT:
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method.

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Dong et al., “Cellular and Humoral Immune Responses to HSV-2 Tegument Proteins in H-2D Mice after DNA Vaccination,”31st International Herpesvirus Workshop, Seattle, WA (2006), Abstract 9.16.
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Nakamura et al., “Codon Usage Tabulated from International DNA Sequence Databases: Status for the Year 2000,”Nucleic Acids Research(2000) 28(1):292, Oxford University Press.

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