Compositions and methods for use of IL-12 as an adjuvant

Details Compositions and methods for use of IL-12 as an adjuvant Compositions and methods for use of IL-12 as an adjuvant

1994-06-17

1996-11-05

Smith, Lynette R. F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4242341, 530350, A61K 3921, A61K 3912, C07K 100, C07K 1400

Patent

active

055715150

ABSTRACT:
Improved vaccine compositions and methods of making the compositions are provided, which vaccines are characterized by an antigen from a pathogen and an effective adjuvanting amount of Interleukin-12 (IL-12). These IL-12 adjuvanted vaccines are capable of increasing the vaccinated host's cell mediated immune response to provide an increased and protective immune response to the pathogen. Also disclosed are methods for vaccinating hosts by administering a vaccine containing an antigen from a pathogenic microorganism and co-administering an adjuvanting amount of IL-12. Vaccines or therapeutic compositions directed against a cancer may also be adjuvanted with IL-12 according to this invention.

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