Compositions and methods for treatment of staphylococcal...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S094630, C435S183000, C435S220000

Reexamination Certificate

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07122514

ABSTRACT:
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans ofstaphylococcicell walls such as lysostaphin and an antibiotic effective againststaphylococcidue to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, evenstaphylococcithat may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include β-lactams and glycopeptides.

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