Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...
Reexamination Certificate
2005-09-06
2005-09-06
Saucier, Sandra E. (Department: 1651)
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
C435S001200, C514S053000, C514S054000, C514S059000, C600S036000
Reexamination Certificate
active
06939668
ABSTRACT:
Methods and compositions for pre-treatment of lung transplants to reduce susceptibility to post-operativeB. cepaciainfection are provided. The methods and compositions employ saccharides, particularly dextrans and xylitol, which are applied to the lung transplant before transplantation.
REFERENCES:
patent: 5441938 (1995-08-01), Speert et al.
patent: 5514665 (1996-05-01), Speert et al.
patent: 5719196 (1998-02-01), Uhari et al.
patent: 6066677 (2000-05-01), Uhari et al.
patent: 6143330 (2000-11-01), Aaltonen et al.
Struber et al., “Flush Perfusion with Low Potassium Dextran Solution Improves Early Graft Function in Clinical Lung Transplantation”, European Journal of Cardio-thoracic Surgery 19 (2) : 190-4 (2001).
Zabner, J., et al., (2000), The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing, PNAS v. 97, pp. 11614-11619.
Kontiokari, T. et al., (1998), Antiadhesive effects of xylitol on otopathogenic bacteria, J. Antimicrobial Chemotherapy, v. 41, pp. 563-565.
Kontiokari, T. et al., (1999), Quantitative analysis of the effect of xylitol on pneumococcal nasal colonisation in rats, FEMS Micro Biol., Lett., v. 178, pp. 313-317.
Uhari, M. et al., (2001), Xylitol in preventing acute otitis media, Vaccine, v. 19, pp. S144-S147.
Klein, J. O., (2000), Nonimmune strategies for prevention of otitis media, Pediatr. Infect. Dis. J., v. 19, pp. S89-S92.
Kontiokari, T. et al., (1995), Effect of Xylitol on Growth of Nasopharyngeal Bacteria In Vitro, Antimicrob. Agents and Chemotherapy, v. 39, pp. 1820-1823.
Moeira et al., (2001), Amer. J. Respir. and Crit Care Med., v. 163, p. A564 (Abstract).
Sajjan, U., et al., (1993), Role of a 22-Kilodalton Pilin Protein in Binding ofPseudomonas cepaciato Buccal Epithelial Cells, Infection and Immunity, v.61, pp. 3157-3163.
Sajjan, U., et al., (1992), Identification of the Mucin-Binding Adhesin ofPseudomonas cepaciaIsolated from Patients with Cystic Fibrosis, Infection and Immunity, v.60, pp. 1434-1440.
Sylvester, F., et al., (1996),Burkholderia(BasonyPseudomonas)cepaciaBinding to Lipid Receptors, Infection and Immunity, v.64, pp. 1420-1425.
Sajjan, U., et al., (2000), Cable-PiliatedBurkholderia cepaciaBinds to Cytokeratin 13 of Epithelial Cells, Infection and Immunity, v.68, pp. 1787-1795.
Govan, J., et al., (1996),Burkholderia cepacia: medical, taxonomic and ecological issues, J. Med. Microbiol, v.45, pp. 395-407.
Speert, D., et al., (1994), Infection withPseudomonas cepaciain Chronic Granulomatous Disease: Role of Nonoxidative Killing by Neutrophils in Host Defense, Journal of Infectious Diseases, v.170, pp. 1524-1531.
Govan, J., et al., (1996), Microbial Pathogenesis in Cystic Fibrosis: MucoidPseudomonas aeruginosaandBurkholderia cepacia, Microbiological Reviews, v.60, pp. 539-574.
Barghouthi, S., (1996), Inhibition by Dextran ofPseudomonas aeruginosaAdherence to Epithelial Cells, Am J Respir Crit Care Med, v.154, pp. 1788-1793.
Forstner Janet
Keshavje Shaf
Sajjan Umadevi
Sajjan Umadevi
Saucier Sandra E.
University Health Network
LandOfFree
Compositions and methods for treatment of lung transplants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treatment of lung transplants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treatment of lung transplants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3418031