Compositions and methods for treatment of infection caused by Ha

Details Compositions and methods for treatment of infection caused by Ha Compositions and methods for treatment of infection caused by Ha

1997-09-23

1999-02-16

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 17, 435 4, 4352534, 435885, 435851, 435 32, C12Q 102, C12Q 150, C12Q 100

Patent

active

058719512

ABSTRACT:
The invention relates to a method of identifying a compound capable of disrupting the addition of choline onto a bacterial cell surface component comprising incubating a sample of bacteria in a solution containing choline in the presence or absence of a test compound, and assessing the effect of the test compound on the addition of choline onto the bacterial cell surface component, wherein a lower level of choline on the cell surface component in the presence of the test compound, compared with the level of choline on the cell surface component in the absence of the test compound, is an indication that the test compound inhibits the addition of choline onto the cell surface component.

REFERENCES:
Altschul et al., 1990, J. Mol. Biol. 215:403-410.
Beiss, 1964, J. Chromatography 13:104-110.
Berry et al. 1995, Infect. Immun. 63:1969-1974.
Fischer et al., 1993, Eur. J. Biochem. 215:851-857.
Fischer et al., 1983, Eur. J. Biochem. 133:523-530.
Fleischmann et al., 1995, Science 269:497-512.
Flugge et al., 1991, Nature 353:364-367.
Glaser et al., 1993, Mol. Microbiol. 10:371-384.
Guidolin et al., 1994, Infect. Immun. 62:5384-5396.
Gulig, et al., 1987, Infect. Immun. 55:513-520.
Harlow et al., 1988, In: Antibodies, A Laboratory Manual, Cold Spring Harbor, NY (too voluminous to submit).
Herriot et al., 1970, J. Bacteriol., 101:517-524.
High et al., 1993, Mol. Microbiol. 9:1275-1282.
Hitchcock et al., 1983, J. Bacteriol. 154:269-277.
Hoiseth et al., 1995, Infect. Immun. 49:389-395.
Inzana, 1983, J. Infect. Dis. 148:492-499.
Johnson et al., 1976, Can. J. Microbiol. 22:29-34.
Kimura et al., 1987, Infect. Immun. 55:1979-1986.
Kimura et al., 1986, Infect. Immun. 51:69-79.
Klugman, 1990, Clin. Microbiol. Rev. 3:171-196.
Ladefoged et al., 1994, J. Bacteriol. 176:5835-5842.
Lamark et al., 1991, Mol. Microbiol. 5:1049-1064.
Leon et al., 1971, Biochemistry 10:1424-1429.
Maskell et al., 1991, Mol. Microbiol. 5:1013-1022.
Michalka, 1969, J. Mol. Biol. 45:407-421.
Mosser et al., 1970, J. Biol. Chem. 245:287-298.
Moxon et al., 1991, Rev. Inf. Dis. 13(suppl.):s518.
Phillips et al., 1993, Biochemistry 32:2003-201.
Povdin et al., 1988, J. Gen. Microbiol. 134:1603-1609.
Raetz, 1996, In: Escherichia coli and Salmonella, pp. 1035-1063, Neidhardt, Eds., ASM Press, Washington, D.C.
Repo et al., 1987, Am. Soc. for Microbiology, pp. 507-512.
Schwarz et al., 1994, J. Biol. Chem. 269:29481-29489.
Schweda et al., 1993, Carbohydrate Research 246:319-330.
Thomas et al., 1978, J. Gen. Microbiology, 109:313-317.
Towbin et al., 1979, Proc. Natl. Acad. Sci. USA 76:4350-4354.
Tuomanen et al., 1995, New Engl. J. Med. 332:1280-1284.
Uchida et al., 1992, J. Biol. Chem. 267:10156-10162.
Weiser et al., 1989, Infect. Immun. 57:3045-3052.
Weiser et al., 1990, J. Bacteriology 172:3304-3309.
Weiser et al., 1990, Infect. Immun. 58:3455-3457.
Weiser, 1993, J. Infect. Dis. 168:672-680.
Weiser et al., 1994, Infect. Immun. 62:2582-2589.
Weiser et al., 1989, Cell 59:657-665.
Whiting et al., 1996, FEMS Microbiology Lett. 138:141-145.
Zamze et al., 1987, Biochem. J. 245:583-587.
Zamze et al., 1987, J. Gen. Microbiol. 133:1443-1451.
Zwahlen et al., 1986, Microbial. Pathogenesis 1:465-473.

Affiliated with

Also associated with

Rating

Compositions and methods for treatment of infection caused by Ha does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for treatment of infection caused by Ha, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treatment of infection caused by Ha will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2061280