Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-02
1998-10-13
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530355, 435 5, C07K 1600, C07K 100, C12Q 170
Patent
active
058213392
ABSTRACT:
A substantially pure preparation of an HSV-specific junction-spanning transcript (L/ST), wherein the 5' end of the L/ST maps to the b repeat sequences of HSV DNA at approximately 3 kb and 125 kb, wherein the L/ST extends into the c repeat sequences of HSV DNA and wherein the HSV DNA sequence encoding the L/ST is preceded by an ICP4 binding site and a TATA box.
REFERENCES:
Baichwal, et al., "Latency Comes of Age for Herpesviruses", Cell, 52, 787-789 (1988).
Batchelor, et al., "Regulation and Cell-Type Specific Activity of a Promoter Located Upstream of the Latency-Associated Transcript of Herpes Simplex Virus Type 1", J. Virology, 64, 3269-3279 (1990).
Bohensky, et al., Identification of a Promoter Mapping within the Reiterated Sequences That Flank the Herpes Simplex Virus Type 1 U.sub.L Region, J. Virology, 67, 632-642 (1993).
Cai, et al., Herpes Simplex Virus Type 1 ICP0 Plays a Critical Role in the De Novo Synthesis of Infectious Virus following Transfection of Viral DNA, J. Virology, 63, 4579-4589 (1989).
Chou, et al., "Mapping of Herpes Simplex Virus-1 Neurovirulence to .gamma.1 34.5, a Gene Nonessential for Growth in Culture", Science, 250, 1262-1266 (1990).
Chou, et al., "The .gamma.1 34.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells", Proc. Natl. Acad. Sci. USA, 89, 3266-3270 (1992).
Davison, A. J., et al., "Nucleotide Sequences of the Joint between the L and S Segments of Herpes Simplex Virus Types 1 and 2", J. Gen. Virology, 55, 315-331 (1981).
DuLuca, et al., "Physical and Functional Domains of the Herpes Simplex Virus Transcriptional Regulatory Protein ICP4", J. Virology, 62, 732-743 (1988).
DeLuca, et al., "Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4", Mol. Cell. Biology, 5, 1997-2008 (1985).
DeLuca, et al., "Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides", Nucl. Acid Res., 15, 4491-4511 (1987).
DeLuca, et al., "Isolation and Characterization of Deletion Mutants of Herpes Simplex Virus Type 1 in the Gene Encoding Immediate-Early Regulatory Protein ICP4", J. Virology, 56, 558-570 (1985).
Devi-Rao, et al., "Relationship between Polyadenylated and Nonpolyadenlated Herpes Simplex Virus Type 1 Latency-Asociated Transcripts", J. Virology, 65, 2179-2190 (1991).
Esparza, et al., "Intertypic Complementation and Recombination between Temnperature-Sensitive Mutants of Herpes Simplex Virus Types 1 and 2", J. Virology, 70, 372-384 (1976).
Frankel, et al., "Cellular Uptake of the Tat Protein from Human Immunodeficiency Virus,", Cell, 55, 1189-1193 (1988).
Greene, et al., "PC12 Pheochromocytoma Cultures in Neurobiological Research", Adv. Cell. Neurobiol., 3, 373-414 (1982).
Green, et al., "Autonomous Functional Domains of Chemically Synthesized Human Immunodeficiency Virus Tat Transactivator Protein", Cell, 55, 1179-1188 (1988).
Hill, et al., "Herpes Simplex Virus Latent Phase Transcription Facilities in Vivo Reactivation", Virology, 174, 117-125 (1990).
Honess, et al., "Regulation of Herpesvirus Macromolecular Synthesis", J. Virology, 14, 8-19, (1974).
Honess, et al., "Regulation of Herpesvirus Macromolecular Synthesis: Sequential Transition of Polypeptide Synthesis Requires Functional Viral Polypeptides", Proc. Natl. Acad. Sci. USA., 72, 1276-1280 (1975).
Imbalzano, et al., "Functional Relevance of Specific Interactions between Herpes Simplex Virus Type 1 ICP4 and Sequences from the Promoter-Regulatory Domain of the Viral Thymidine Kinase Gene", J. Virology, 64, 2620-2631 (1990).
Jones, et al., "Transacting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses", Genes & Dev., 2, 267-281 (1988).
Jones, et al., "A Cellular DNA-Binding Protein that Activates Eukaryotic Transcription and DNA Replication", Cell, 48, 79-89 (1987).
Krause, et al., "Detection and Preliminary Characterization of Herpes Simplex Virus Type 1 Transcripts in Latently Infected Human Trigeminal Ganglia", J. Virology, 62, 4819-4823.
Leib, et al., "Immediate-Early Regulatory Gene Mutants Define Different Stages in the Establishment and Reactivation of Herpes Simplex Virus Latency", J. Virology, 63, 1757-768 (1989).
Leib, et al., "A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Reactivates from the Latent State with Reduced Frequency", J. Virology, 63, 2893-2900, (1989).
McCarthy, et al., "Herpes Simplex Virus Type 1 ICP27 Delection Mutants Exhibit Altered Patters of Transcriptional and Are DNA Deficient", J. Virology, 63, 18-27 (1989).
McGeoch, et al., "Sequence Determination and Genetic Content of the Short Unique Region in the Genone of Herpes Simplex Virus Type 1", J. Mol. Biology, 181, 1-13 (1985).
McGeoch, et al., "Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2", J. Gen., Virology, 72, 3057-3075 (1991).
Meek, et al., "Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptode analogues", Nature, 343, 90-92 (1990).
Mitchell, et al., "Mapping of low abundance latency-associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1", J. Gen. Virology, 71, 125-132 (1990).
Murchie, et al., "DNA Sequence Analysis of an Immediate-Early Gene Region of the Herpes Simplex Virus Type 1 Genome (Map Coordinates 0.950 to 0.978)", J. Gen. Virology, 62,1-15 (1982).
Sacks, et al., "Deletion Mitants in the Gene Encoding the Herpes Simplex Viruse Type 1 Immediate-Early Protein ICP0 Exhibit Impaired Growth in Cell Culture", J. Virology, 61, 829-839 (1987).
Sacks, "Herpes Simplex Virus Type 1 ICP27 is an Essential Regulatory Protein", J. Virology, 55, 796-805 (1985).
Schaffer, et al., "Collaborative Commplementation Study of Temperature-Sensitive Complementation Study of Temperature-Sensitive Mutants of Herpes Simplex Virus Types 1 and 2", J. Virology, 490-504 (1978).
Smiley, et al., "The Herpes Simplex Virus Type 1 (HSV-1) a Sequence Serves as a Cleavage/Packaging Signal but Does Not Drive Recombinational Genome Isomerization When it is Inserted into the HSV-2 Genome", J. Virology, 66, 7505-7510 (1992).
Spivak, et al., "Detection of Herpes Simplex Virus Type 1 Transcripts during Latent Infection in Mice", J. Virology, 61, 3841-3847 (1987).
Stevens, et al., "RNA Complementary to a Herpesvirus .alpha. Gene mRNa is Prominent in Latently Infected Neurons", Science, 235, 1056-1059 (1987).
Trousdale, et al., "In Vivo and In Vitro Reactivation Impairment of a Herpes Simplex Virus Type 1 Latency-Associated Transcript Variant in a Rabbit Eye Model", J. Virology, 65, 6989-6993 (1991).
Wagner, et al., "The Herpes Simplex Virus Latency-Associated Transcript is Spliced during the Latent Phase of Infection", J. Virology, 62, 4577-4585 (1988).
Weller, et al., "Genetic Analysis of Temperature-Sensitive Mutants which Define the Gene for the Major Herpes Simplex Virus Type 1 DNA-Binding Protein", J. Virology, 45, 354-366 (1983).
Zwaagstra, et al., "Activity of Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Promoter in Neuron-Derived Cells: Evidence for Neuron Specificity and for a Large LAT Transcript", J. Virology, 64, 5019-5028 (1990).
Baichwal V et al, Latency comes of age for herpesvirus, Cell 52:787-789, Mar. 1988.
Stevens J et al, RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons, Science 235:1056-1059, Feb. 1987.
Farrell M et al, Herpes simplex virus latency-associated transcript is a stable intron, Proc. Nat'l Acad. Sci. 88:790-794, Feb. 1991.
Doerig C et al, An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1, J. Virol. 65(5):2724-2727, May 1991.
Cheung A et al, Cloning of the latency gene and the early protein O gene of pseudorabies virus, J. Virol. 65(10):5260-5271, Oct. 1991.
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Schaffer Priscilla A.
Yeh Lily
Achutamurthy Ponnathapura
Dana Farber Cancer Institute
Park Hankyel T.
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