Compositions and methods for treating obesity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S757000, C424S641000

Reexamination Certificate

active

07144865

ABSTRACT:
The present invention relates to dietary supplementing methods useful for controlling obesity. More particularly, the invention relates to methods of administration of compositions containing defined chemical species useful for prevention and treatment of obesity. In a preferred embodiment, pharmaceutical compositions used in connection with the present invention comprise: (1) a zinc salt, (2) cyclo-Hispro and/or (3) arachidonic acid, and (4) at least one pharmaceutically acceptable excipient. More particularly, the invention relates to methods of manufacturing of preparing a soybean protein hydrolysate (SPH) comprising cyclo-Hispro.

REFERENCES:
patent: 4273763 (1981-06-01), Horrobin
patent: 5411748 (1995-05-01), Song
patent: 5418218 (1995-05-01), Wilber
patent: 5834032 (1998-11-01), Song
patent: 5904926 (1999-05-01), Slavin
patent: 5989574 (1999-11-01), Slavin
patent: 5997908 (1999-12-01), Song
Russo et al. Hypertension. 1997. vol. 29, No. 4, pp. 1058-1063, MEDLINE Abstract enclosed.
Eder et al. J. Nutritional Biochem. 1997. vol. 8, No. 8, pp. 461-468, EMBASE Abstract enclosed.
Effect of arachidonic acid plus zinc on glucose disposal in genetically diabetic(ob/ob)mice, I.K. Hwang et al.,Diabetes, Obesity and Metabolism, Apr. 2002, pp. 124-131.
Antidiabetic Actions of Arachidonic Acid and Zinc in Genetically Diabetic Goto-Kakizaki Rats, Moon K. Song et al.,Metabolism, vol. 52, No. 1 (Jan.), 2003; pp. 7-12.
Synergistic Antidiabetic Activities of Zinc, Cyclo(His-Pro),and Arachidonic Acid, Moon K. Song et al.,Metabolism, vol. 50, No. 1 (Jan.), 2001; pp. 53-59.
Animal Prostate Extract Ameliorates Diabetic Symptoms by Stimulating Intestinal Zinc Absorption in Rats, M.K. Song et al.,Diabetes Research(1996), 31: pp. 157-170.
Metabolism of Glucose by Rat Pancreatic Islets and Kidney: Comparison of Membrane Preparations with Intact Tissue, Moon K. Song et al.,Pancreas, vol. 24, No. 2, 2002, pp. 205-209.
Effects of Bovine Prostate Powder on Zinc, Glucose, and Insulin Metabolism in Old Patients with Non-Insulin-Dependent Diabetes Mellitus, M.K. Song et al.,Metabolism, vol. 47, No. 1 (Jan. ), 1998, pp. 39-43.
Effects of arachidonic acid and cyclo (his-pro) on zinc transport across small intestine and muscle tissues; M.J. Rosenthal et al.,Life Sciences70 (2001) 337-348.
Anti-Hyperglycemic Activity of Zinc Plus Cyclo(His-Pro)in Genetically Diabetic Goto-Kakizaki and Aged Rats, Moon K. Song et al.,Control of Diabetes by Cyclo(His-Pro), pp. 1338-1345, 2003.
Effects of cyclo(his-pro)plus zinc on glucose metabolism in genetically diabetic obese mice, I.K. Hwang et al.,Diabetes, Obesity and Metabolism, May 2003, pp. 317-324.

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