Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-19
2008-03-04
Ungar, Susan (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S069700, C435S258100, C435S258200, C424S185100, C424S094400, C514S002600, C514S012200, C530S300000, C530S350000
Reexamination Certificate
active
07338766
ABSTRACT:
The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells byP. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.
REFERENCES:
patent: 6551795 (2003-04-01), Rubenfield et al.
patent: 2003/0059436 (2003-03-01), Chishti rt al.
patent: WO 02/76380 (2002-10-01), None
patent: WO 2005018662 (2005-03-01), None
Fundamental Immunology 242 (William E. Paul, M.D. ed ., 3d ed. 1993).
Accession No. P00282.
Hoitink et al Gene vol. 90, Issue 1, May 31, 1990, pp. 15-20.
Canters and Gilardi FEBS Letters vol. 325, Issues 1-2, Jun. 28, 1993, pp. 39-4.
Nar et al FEBS Letters vol. 306, Issues 2-3, Jul. 20, 1992, pp. 119-124.
Kamp et al Biochimica et Biophysica Acta (BBA)—Bioenergetics vol. 1019, Issue 3, Sep. 19, 1990, pp. 283-292.
Yamada T, et al., “Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity”,Cell Microbiol. Oct. 2005;7(10);1418-31.
Yamada T, et al., “Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells”,Cell CycleSep. 2004;3(9):1182-7.
Yamada T, et al., “Regulation of mammalian cell growth and death by bacterial redox proteins: relevance to ecology and cancer therapy”,Cell CycleJun. 2004;3(6):752-5.
Hiraoka Y, et al., “Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c”,Proc Natl Acad SciU S A. Apr. 27, 2004;101(17):6427-32.
Yamada T, et al., “Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin”,Proc Natl Acad SciU S A. Apr. 6, 2004;101(14):4770-5.
Punj V, et al., “Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer”,OncogeneMar. 25, 2004;23(13):2367-78.
Chakrabarty Am, “Microorganisms and Cancer: Quest for a Therapy”,J. Bacteriol. 185(9):2683-86.
Punj V, et al., “BacterialCupredoxin azurinand its interactions with the tumor suppressor protein p53”,Biochem Biophys Res Commun. Dec. 5, 2003;312(1):109-14.
Punj V, et al., “Energy-generating enzymes ofBurkholderia cepaciaand their interactions with macrophages”,J Bacteriol. May 2003;185(10):3167-78.
Goto M, et al., “Induction of apoptosis in macrophages byPseudomonas aeruginosaazurin: tumour-suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity”,Mol Microbiol. Jan. 2003; 47(2):549-59.
Yamada T, et al., “The Bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53”,Infect Immun. Dec. 2002;70(12):7054-62.
Yamada T, et al., “Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer”,Proc Natl Acad SciU S A. Oct. 29, 2002;99(22):14098-103. Epub Oct. 22, 2002.
Zaborina O, et al., “P2Z-Independent and P2Z receptor-mediated macrophage killing byPseudomonas aeruginosaisolated from cystic fibrosis patients”,Infect Immun. Oct. 1999; 67(10):5231-42.
Zaborina O, et al., “Secreted products of a nonmucoidPseudomonas aeruginosastrain induce two modes of macrophage killing: external-ATP-dependent, P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis”,Microbiology, Oct. 2000;146 (Pt 10):2521-30.
Yang D., et al., “Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells”,Pharmacological Research2005 52(5):413-421.
Apiyo D. and Wittung-Stafshede, P., “Unique complex between bacterial azurin and tumor-suppressor protein p53”,Bioche. Biophys. Res. Comm. 2005 332: 965-968.
Ye, Z., et al. “Selective inducement effect of bacterial redox protein azurin on apoptosis of human osteosarcoma cell line U2OS”,Chinese Journal of Cancer2005, 24(3): 298-304.
Yamada et al., “The Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53”,Infection and Immunity, vol. 70(12), Dec. 2002, pp. 7054-7062.
Anonymous: “Plastocyanin precursor” Database EMBL, Online, Nov. 1, 1997, XP002306632 abstract.
Anonymous: “Rusticyanin precursor” Database EMBL, Online, Mar 1, 1992, XP002306633 abstract.
Anonymous: “Pseudoazurin precursor” Database EMBL, Online, Feb. 1, 1991, XP002306634 abstract.
Navy Environment Health Center; Bureau of Medicine and Surgery. “Navy Medical Dept. Pocket Guide to Malaria Prevention and Control.” Technical Manual NEHC-TM PM 6250.1 (Sep. 2000).
Chakrabarty Ananda
Chaudhari Anita
Das Gupta Tapas
Fialho Arsenio
Hong Chang Soo
Baskar Padma
Sheppard Mullin Richter & Hampton LLC
The Board of Trustees of the University of Illinois
Ungar Susan
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