Compositions and methods for treating infections using...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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C530S324000, C530S326000, C530S327000, C530S328000, C514S002600, C424S009100

Reexamination Certificate

active

10277233

ABSTRACT:
Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.

REFERENCES:
patent: 4510132 (1985-04-01), Vaara
patent: 5324716 (1994-06-01), Selsted et al.
patent: 5359030 (1994-10-01), Ekwuribe
patent: 5438040 (1995-08-01), Ekwuribe
patent: 5523288 (1996-06-01), Cohen et al.
patent: 5547939 (1996-08-01), Selsted
patent: 5574017 (1996-11-01), Gutheil
patent: 5578572 (1996-11-01), Horwitz et al.
patent: 5593866 (1997-01-01), Hancock et al.
patent: 6040435 (2000-03-01), Hancock et al.
patent: 6180604 (2001-01-01), Fraser et al.
patent: 6191254 (2001-02-01), Falla et al.
patent: 6503881 (2003-01-01), Krieger et al.
patent: 6538106 (2003-03-01), Fraser et al.
patent: 2004/0009910 (2004-01-01), Fraser et al.
patent: 590 070 (1998-02-01), None
patent: WO 91/12815 (1991-09-01), None
patent: WO 92/22308 (1992-12-01), None
patent: WO 95/22338 (1995-08-01), None
patent: WO 96/38473 (1996-12-01), None
patent: WO 97/04796 (1997-02-01), None
patent: WO 97/08199 (1997-03-01), None
patent: WO 97/31942 (1997-09-01), None
patent: WO 98/07745 (1998-02-01), None
patent: WO 98/45319 (1998-10-01), None
patent: WO 99/43357 (1999-09-01), None
Brewer NS, 1977, Antimicrobial agents—Part II. The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, neomycin, Mayo Clin. Proc., 52(11): Abstract only.
Sherris (Ryan ed.), 1994, Medical Microbiology: An Introduction to Infectious Diseases, Appleton & Lange Paramount Publishing Business and Professional Group, Third Edition, pp. 285, 295, 353, and 385.
Perez-Soler R, 1989, Liposomes as carriers of antitumor agents: toward a clinical reality, Cancer Treat. Rev., 16(2): Abstract only.
Chalk et al., “Purification of An Insect Defensin from the Mosquito,Aedes aegypti,” Insect Biochem. Molec. Biol. 24(4):403-410, 1994.
Chalk et al., “Full Sequence and Characterization of Two Insect Defensins: Immune Peptides from the MosquitoAedes aegypti,” Proc. R. Soc. Land. B. 261(1361):217-221, 1995.
Darveau et al., “β-Lactam Antibiotics Potentiate Magainin 2 Antimicrobial Activity In Vitro and In Vivo,”Antimicrobial Agents&Chemotherapy 35(6):1153-1159, 1991.
Engström et al., “The Antibacterial Effect of Attacins from the Silk MothHyalophora cecropiais Directed Against the Outer Membrane ofEscherichia coli,” EMBO J. 3(13):3347-3351, 1984.
Falla et al., “Mode of Action of the Antimicrobial Peptide Indolicidin,”The Journal of Biological Chemistry 271(32): 19298-19303, Aug. 9, 1996.
Hancock, “The Role of Fundamental Research and Biotechnology in Finding Solutions to the Global Problem of Antibiotic Resistance,”Clin. Infectious Diseases 24(Supp 1)S148-S150, 1997.
Ladokhin et al., “CD Spectra of Indolicidin Antimicrobial Peptides Suggest Turns, Not Polyproline Helix,”Biochemistry 38:12313-12319, 1999.
Lawyer et al., “Antimicrobial Activity of a 13 Amino Acid Tryptophan-Rich Peptide Derived From a Putative Porcine Precursor Protein of a Novel Family of Antibacterial Peptides,”FEBS Letters 390:95-98, 1996.
Piers et al., “Improvement of Outer Membrane-Permeabilizing and Lipopolysaccharide-Binding Activities of an Antimicrobial Cationic Peptide by C-Terminal Modification,”Antimicrobial Agents&Chemotherapy 38(10):2311-2316, 1994.
Robinson, Jr. et al., “Anti-HIV-1 Activity of Indolicidin, an Antimicrobial Peptide from Neutrophils,”Journal of Leukocyte Biology 63:94-100, 1998.
Selsted et al., “Purification, Characterization, Synthesis and cDNA Cloning of Indolicidin: A Tryptophan-Rich Microbicidal Tridecapeptide from Neutrophils,”Proceedings of the 12thAmerican Peptide Symposium, Jun. 16-21, 1991, Cambridge, MA, pp. 905-907.
Subbalakshmi et al., “Interaction of Indolicidin, a 13-Residue Peptide Rich in Tryptophan and Proline and its Analogues with Model Membranes,”J. Biosci. 23(1):9-13, 1998.
Tanchak et al., “Tryptophanins: Isolation and Molecular Characterization of Oat cDNA Clones Encoding Proteins Structurally Related to Puroindoline and Wheat Grain Softness Proteins,”Plant Science 137:173-184, 1998.
Uchida et al., “Structure-Activity of Antibacterial Peptide Indolicidin and Analogs,”Peptide Science, pp. 221-224, 1998.
Van Abel et al., “Synthesis and Characterization of Indolicidin, a Tryptophan-Rich Antimicrobial Peptide from Bovine Neutrophils,”Int. J. Peptide Protein Res. 45:401-409, 1995.
Vaara, “The Outer Membrane as the Penetration Barrier Against Mupirocin in Gram-Negative Enteric Bacteria,”J. Antimicrob. Chemother. 29(2):221-222, 1992.
Vaara, “Agents That Increase the Permeability of the Outer Membrane,”Microbiological Reviews 56(3):395-411, 1992.
Vaara and Porro, “Group of Peptides That Act Synergistically with Hydrophobic Antibiotics Against Gram-Negative Enteric Bacteria,”Antimicrobial Agents&Chemotherapy 40(8):1801-1805, 1996.
Vaara and Vaara, “Polycations Sensitize Enteric Bacteria to Antibiotics,”Antimicrobial Agents&Chemotherapy 24(1):107-113, 1983.
Vaara and Vaara, “Sensitization of Gram-Negative Bacteria to Antibiotics and Complement by a Nontoxic Oligopeptide,”Nature 303:526-528, 1983.
Vaara and Vaara, “Ability of Cecropin B to Penetrate the Enterobacterial Outer Membrane,”Antimicrobail Agents&Chemotherapy 38(10):2498-2501, 1994.
Wakabayashi et al., “N-Acylated and D Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity,”Antimicrobial Agents And Chemotherapy 43(5):1267-1269, May 1999.
Bundgaard, H., “Design of prodrugs: Bioreversible derivatives for various functional groups and chemical entities,” Chapter 1, pp. 1-92 inDesign of Prodrugs, Bundgaard, H.(Ed.), Elsevier Science Publishers B.V. (Biomedical Division), 1985.
Falla and Hancock, “Improved Activity of a Synthetic Indolicidin Analog,”Antimicrobioal Agents and Chemotherapy 41(4): 771-775, Apr. 1997.
Selsted et al., “Indolicidin, a Novel Bactericidal Tridecapeptide Amide from Neutrophils,”The Journal of Biological Chemistry 267(7): 4292-4295, Mar. 5, 1992.
Subbalakshmi and Sitaram, “Mechanism of antimicrobial action of Indolicidin,”FEMS Microbiology Letters 160: 91-96, 1998.
Subbalakshmi et al., “Requirements for antibacterial and hemolytic activities in the bovine neutrophil derived 13-residue peptide Indolicidin,”FEBS Letters 395: 48-52, 1996.
Uchida et al., “Antibacterial Activity of the Mammalian Host Defense Peptide, Indolicidin, and Its Fragments,” inPeptide Chemistry, N. Nishi (Ed.), Protien Research Foundation, Osaka, 1996, pp. 229-232.

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