Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-11-27
2007-11-27
Campell, Bruce R. (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C514S002600
Reexamination Certificate
active
11436591
ABSTRACT:
The present invention relates to cupredoxin, specificallyPseudomonas aeruginosaazurin, and/orPseudomonas aeruginosacytochrome C551and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
REFERENCES:
patent: 6375925 (2002-04-01), Tsimikas et al.
patent: 6551795 (2003-04-01), Rubenfield et al.
patent: WO 02/076380 (2002-10-01), None
Accession No. P00282.
Murphy et al., Structural characterization of azurin fromPseudomonas aeruginosaand some of its methionine0121 mutants, Biochemistry, 1993, vol. 32, pp. 1965-1975.
Kamp et al., Biochimica et Biophysica Acta (BBA)—Bioenergetics, vol. 1019, Issue 3, Sep. 19, 1990, pp. 283-292.
Hoitink et al., Gene, vol. 90, Issue 1, May 31, 1990, pp. 15-20.
Canters and Gilardi, FEBS Letters, vol. 325, Issue 1-2, Jun. 28, 1993, pp. 39-4.
Nar et al., FEBS Letters vol. 306, Issue 2-3, Jul. 20, 1992, pp. 119-124.
Yamada et al., “Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53”,Infection and Immunity, vol. 70 (12), Dec. 2002, pp. 7054-7062.
Anonymous: “Plastocyanin precursor” DATABASE EMBL, Online, Nov. 1, 1997, XP002306632 abstract.
Anonymous: “Rusticyanin precursor” DATABASE EMBL, Online, Mar. 1, 1992, XP002306633 abstract.
Anonymous: “Pseudoazurin precursor” DATABASE EMBL, Online, Feb. 1, 1991, XP002306634 abstract.
Yamada T, et al., “Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity”,Cell Microbiol. Oct. 2005;7(10):1418-31.
Yamada T, et al., “Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells”,Cell CycleSep. 2004;3(9):1182-7.
Yamada T, et al., “Regulation of mammalian cell growth and death by bacterial redox proteins: relevance to ecology and cancer therapy”,Cell CycleJun. 2004;3(6):752-5.
Hiraoka Y, et al., “Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c”,Proc Natl Acad Sci U S A. Apr. 27, 2004;101(17):6427-32.
Yamada T, et al., “Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin”,Proc Natl Acad Sci U S A. Apr. 6, 2004;101(14):4770-5.
Punj V, et al., “Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer”,OncogeneMar. 25, 2004;23(13):2367-78.
Chakrabarty AM, “Microorganisms and Cancer: Quest for a Therapy”,J. Bacteriol. 185(9):2683-86, (2003).
Punj V, et al., “Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53”,Biochem Biophys Res Commun. Dec. 5, 2003;312(1):109-14.
Punj V, et al., “Energy-generating enzymes ofBurkholderia cepaciaand their interactions with macrophages”,J Bacteriol. May 2003;185(10):3167-78.
Goto M, et al., “Induction of apoptosis in macrophages byPseudomonas aeruginosaazurin: tumour-suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity”,Mol Microbiol. Jan. 2003;47(2):549-59.
Yamada T, et al., “The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53”,Infect Immun. Dec. 2002;70(12):7054-62.
Yamada T, et al., “Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer”,Proc Natl Acad Sci U S A. Oct. 29, 2002;99(22):14098-103. Epub Oct. 22, 2002.
Zaborina O, et al., “P2Z-Independent and P2Z receptor-mediated macrophage killing byPsuedomonas aeruginosaisolated from cystic fibrosis patients”,Infect Immun. Oct. 1999;67(10):5231-42.
Zaborina O, et al., “Secreted products of a nonmucoidPseudomonas aeruginosastrain induce two modes of macrophage killing: external-ATP-dependent, P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis”,MicrobiologyOct. 2000;146 ( Pt 10):2521-30.
Yang D., et al., “Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells”,Pharmacological Research2005 52(5):413-421.
Aplyo D. and Wittung-Stafshede, P., “Unique complex between bacterial azurin and tumor-suppressor protein p53”,Bioche. Biophys. Res. Comm. 2005 332: 965-968.
Ye, Z., et al. “Selective inducement effect of bacterial redox protein azurin on apoptosis of human osteosarcoma cell line U2OS”,Chinese Journal of Cancer2005, 24(3): 298-304.
Chakrabarty Ananda
Chaudhari Anita
Das Gupta Tapas
Fialho Arsenio
Hong Chang Soo
Campell Bruce R.
Kinsey Nicole E
Sheppard Mullin Richter & Hampton LLP
The Board of Trustees of the University of Illinois
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