Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-06-30
1997-06-17
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514177, 514250, 514254, 514410, A61K 3156, A61K 31495, A61K 3150, A61K 3140
Patent
active
056397437
ABSTRACT:
Methods and compositions for the prevention or reversal of exocrine gland atrophy, especially lacrimal gland atrophy, by maintaining normal physiological levels of prolactin are described. In the preferred embodiment, exogenous prolactin or a substance that modulates endogenous prolactin secretion is administered to a mammal in combination with an androgen, such as testosterone. The combination acts synergistically to maintain or restore normal prolactin concentrations, resulting in the maintenance or restoration of gland mass and function. Administration of prolactin and androgen in combination with estrogen is particularly useful in the treatment of lacrimal gland dysfunction in post-menopausal women or women who have undergone ovariohysterectomies.
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Kaswan Renee
Mircheff Austin K.
Warren Dwight W.
Criares Theodore J.
University of Georgia Research Foundation
University of Southern California
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