Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-25
1999-09-28
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 48, 514381, 514396, 514397, 514400, A61K 3141, A61K 3170, A61K 3808
Patent
active
059588845
ABSTRACT:
Methods and compositions for treating patients having erectile dysfunction are described. The method involves the step of treating a patient with a combination of an AT.sub.1 specific Angiotensin II antagonist and Angiotensin II agonist. Preferably the AT.sub.1 specific Angiotensin II antagonist is an AT.sub.1 specific Angiotensin II antagonist. The composition is a pharmaceutical composition including an equivalent molecular ratio of an AT.sub.1 specific Angiotensin II antagonist and Angiotensin II agonist.
REFERENCES:
patent: 5278192 (1994-01-01), Fung et al.
patent: 5475004 (1995-12-01), Heitsch et al.
patent: 5658936 (1997-08-01), Kifor et al.
Andersson et al. Physiology of Penile Erection. Physiol. Reviews. vol. 75, No. 1, pp. 191-218, Jan. 1995.
Venegas, J., et al., "Assessment and modeling . . . ", Modeling in Physiology, H2109-2123 (1995).
Comiter, C., et al., "Urodynamic Risk Factors . . . ", J. of Urology, (1997), 158:181-185.
Braley, et al., "The Effects of Extra . . . ", Biochem. and Biophys. Res. Com., (1984), 123:2:810-815.
Price, et al., "Renin System Autonomy . . . ", 29th Annual Meeting, (1996), Abstract.
Price, et al., "The Paradox of the . . . ", 29th Annual Meeting, (1996), Abstract.
Price, et al., "Renal Perfusion is . . . ", 31st Annual Meeting, (1998), Abstract.
Persson, K., "Angiotensin II and Bladder . . . ", 1996, Abstract, Amer. J. Physiol. 271:5:1-2 R1186-1192.
Klinge, E., et al., "Comparative Study of Some Isolated Mammalian Smooth Muscle Effectors of Penile Erection", ACTA, Physiol, Scand, 1997, 100:354-367.
Croog, S., et al., "Sexual Symptoms in Hypertensive Patient", Arch. Intern. Med., 1988, 148:788-794.
Clark, J., "A Possible Role for Angiotensin II in the Regulation of Male Sexual Behavior in Rats". Physiology and Behavior, 45:221-246 (1989).
Suzuki, H., et al., "Effects of First-Line Antihypertensive Agents on Sexual Function and Sex Hormones". Journal of Hypertension, 1988, 6(suppl 4): S649-S651.
Walley, T., et al., Adverse Effects of Captopril in Hospital Outpatients with Hypertension:, Post Grad Med Journal, 1990, 66:106-109.
Vickers, M., et al., "Angiotensin Production by Human Corporal Cavernosal Tissue". The Journal of Urology, 1992, 147:4, No. 100.
Haidle, G., et al., "Guidelines for Drug Treatment of Male Infertility", Drugs, 1:160-68 (1991).
Testa, M., et al., "Quality of Life and Antihypertensive Therapy in Men-A Comparison of Captopril with Enalapril". The New England Journal of Medicine, 1993, 328:907-913.
Goldstein, I., et al., "Impotence". 62nd Annual Meeting Program of the New England Section, American Urological Association, Inc--Session II, 1993, pp. 64-65.
Joubert, P., et al., "The Effects of papervine, Prostaglandin E-1, and Phenylephrine on the Pulsatile Angiotensin II Secretion by Human Corporal Cavernosal Tissue", Journal of Urology, 1993 149:4:245A. No. 125.
Lopes-Martins, R., "Pharmacological Characterization of Rabbit Corpus Cavernosum Relaxation Mediated by the Tissue Kallikrein-kinin System", Br. J. Pharmacol, 1994, 113:81-86.
Prisant, L.M., et al., "Sexual Dysfunction with Antihypertensive Drugs". Arch Intern Med, 1994, 154:730-736.
Kifor, I., et al., "Tissue Angiotensin II and Impotence", The Endocrine Society, 1995 Abstract Form, Jan. 1995.
Andersson, K., et al., "Characterization of Immunoreactive . . . ", J of Urology, 1987, 137:1278-1282.
Kifor Imre
Williams Gordon
Russel Jeffrey E.
The Brigham and Women's Hospital, Inc.
LandOfFree
Compositions and methods for treating erectile dysfunction does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treating erectile dysfunction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treating erectile dysfunction will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-703234