Compositions and methods for treating diseases associated...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100, C536S024500, C530S387100

Reexamination Certificate

active

07981615

ABSTRACT:
The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.

REFERENCES:
patent: 6506559 (2003-01-01), Fire et al.
Cai et al., Development. May 2005;132(10):2475-87. Epub Apr. 20, 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.
Elbashir et al., The EMBO Journal, vol. 20, No. 23, pp. 6877-6888, 2001.
Devroe and Silver, “Retrovirus-Delivered siRNA,”BMC Biotechnology(2002), 2(15):1-5.
Mahato et al., “Modulation of Gene Expression by Antisense and Antigene Oligodeoxynucleotides and Small Interfering RNA,”Expert Opin. Drug Deliv. (2005), 2(1):3-28, Ashley Publications Ltd.
Prince et al., “Tbx2 Directly Represses the Expression of the p21WAF1Cyclin-Dependent Kinase Inhibitor,”Cancer Research(2004), 64:1669-1674.
Scherer and Rossi, “Approaches for the Sequence-Specific Knockdown of mRNA,”Nature Biotechnology(2003), 21(12):1457-1465, Nature Publishing Group.

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