Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-07-19
2011-07-19
Bowman, Amy (Department: 1635)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024500, C530S387100
Reexamination Certificate
active
07981615
ABSTRACT:
The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.
REFERENCES:
patent: 6506559 (2003-01-01), Fire et al.
Cai et al., Development. May 2005;132(10):2475-87. Epub Apr. 20, 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.
Elbashir et al., The EMBO Journal, vol. 20, No. 23, pp. 6877-6888, 2001.
Devroe and Silver, “Retrovirus-Delivered siRNA,”BMC Biotechnology(2002), 2(15):1-5.
Mahato et al., “Modulation of Gene Expression by Antisense and Antigene Oligodeoxynucleotides and Small Interfering RNA,”Expert Opin. Drug Deliv. (2005), 2(1):3-28, Ashley Publications Ltd.
Prince et al., “Tbx2 Directly Represses the Expression of the p21WAF1Cyclin-Dependent Kinase Inhibitor,”Cancer Research(2004), 64:1669-1674.
Scherer and Rossi, “Approaches for the Sequence-Specific Knockdown of mRNA,”Nature Biotechnology(2003), 21(12):1457-1465, Nature Publishing Group.
Cai Chenleng
Chen Ju
Evans Sylvia
Rosenfeld Michael G.
Zhou Wenlai
Bowman Amy
DLA Piper (LLP) US
The Regents of the University of California
LandOfFree
Compositions and methods for treating diseases associated... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treating diseases associated..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treating diseases associated... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2679654