Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-20
2005-09-20
Harris, Alana M. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S006120, C435S007100, C435S040500, C436S063000, C436S064000, C530S358000
Reexamination Certificate
active
06946259
ABSTRACT:
This invention provides methods by which test substances can be screened for their ability to inhibit, enhance or eliminate double minute (DM) or extrachromosomal DNA by micronucleation in cells. This invention also provides a method for inducing maturation or death of a cell having the capacity to generate micronuclei. It also provides a method of treating a disease in a subject, the cells correlated with the disease having DM and extrachromosomal DNA as well as the capacity to generate micronuclei to capture them. Further provided is a method of detecting chromosomal and extrachromosomal DNA in a cell.
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Kanda Teru
Shepard H. Michael
Shimizu Noriaki
Wahl Geoffrey M.
Harris Alana M.
Holleran Anne L.
McDermott Will & Emery LLP
The Salk Institute For Biological Studies
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