Compositions and methods for treating cancer

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

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Reexamination Certificate

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10407864

ABSTRACT:
This invention provides compositions and methods for treating neoplasias in a mammal. In particular, the invention provides liposome-encapsulated vinca alkaloids, e.g., vinorelbine, and methods of treating a mammal using such compositions.

REFERENCES:
patent: 4186183 (1980-01-01), Steck et al.
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4261975 (1981-04-01), Fullerton et al.
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774085 (1988-09-01), Fidler
patent: 4837028 (1989-06-01), Allen
patent: 4885172 (1989-12-01), Bally et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4952408 (1990-08-01), Rahman
patent: 4957773 (1990-09-01), Spencer et al.
patent: 5023087 (1991-06-01), Yau-Young
patent: 5059421 (1991-10-01), Loughrey et al.
patent: 5077056 (1991-12-01), Bally et al.
patent: 5165922 (1992-11-01), Hellstrom et al.
patent: 5171578 (1992-12-01), Bally et al.
patent: 5534499 (1996-07-01), Ansell
patent: 5543152 (1996-08-01), Webb et al.
patent: 5552156 (1996-09-01), Burke
patent: 5567592 (1996-10-01), Benet et al.
patent: 5595756 (1997-01-01), Bally et al.
patent: 5714163 (1998-02-01), Forssen et al.
patent: 5736155 (1998-04-01), Bally et al.
patent: 5741516 (1998-04-01), Webb et al.
patent: 5755788 (1998-05-01), Strauss
patent: 5785987 (1998-07-01), Hope et al.
patent: 5814335 (1998-09-01), Webb et al.
patent: 5820873 (1998-10-01), Choi et al.
patent: 5837282 (1998-11-01), Fenske et al.
patent: 5885613 (1999-03-01), Holland et al.
patent: 5976567 (1999-11-01), Wheeler et al.
patent: 6056973 (2000-05-01), Allen et al.
patent: 6110491 (2000-08-01), Kirpotin
patent: 6320017 (2001-11-01), Ansell
patent: 6355268 (2002-03-01), Slater et al.
patent: 6471943 (2002-10-01), Placke et al.
patent: 6566395 (2003-05-01), Moran
patent: 6723338 (2004-04-01), Sarris et al.
patent: 2003/0147945 (2003-08-01), Tardi et al.
patent: WO 91/17424 (1991-11-01), None
patent: WO 95/08986 (1995-04-01), None
patent: WO 98/17256 (1998-04-01), None
patent: WO 99/13816 (1999-03-01), None
patent: WO 99/51202 (1999-10-01), None
patent: WO 00/23052 (2000-04-01), None
U.S. Appl. No. 08/316,394 entitled “Glycosylated Protein-Liposome Conjugates and Methods for their Preparation,” filed Sep. 30, 1994.
U.S. Appl. No. 08/316,407 entitled “Bilayer Stabilizing Components and their use in Forming Programmable Fusogenic Liposomes,” filed Sep. 30, 1994.
U.S. Appl. No. 08/996,783 entitled “Polyamide Oligomers,” filed Feb. 2, 1998.
Bloomfield, V., “Quasi-Elastic Light Scattering Application in Biochemistry and Biology,”Ann. Rev. Biophys. Bioeng. 10:421-450, 1981.
Burris, H. et al., “Activity of Topotecan, a New Topoisomerase I Inhibitor, Against Human Tumor Colony-Forming Units in Vitro,”J. Natl. Cancer Inst. 84(23):1816-1825, Dec. 1992.
Chu, E. et al.,Physician's Cancer Chemotherapy Drug Manual 2002, Jones and Bartlett Publishers, Sudbury, Massachusetts, 2002.
Clements, M. et al., “Antiangiogenic Potential of Camptothecin and Topotecan,”Cancer Chemother. Pharmacol. 44:411-416, 1999.
Corbett, T. et al.,Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Humana Press Inc., Totowa NJ, 1997, Ch. 5, “In Vivo Methods for Screening and Preclinical Testing” pp. 75-99.
Deamer, D. et al., “Larger Volume Liposomes by an Ether Vaporization Method,”Biochim. et Biophys. Acta 443:629-634, 1976.
Dumontet, C. et al., “Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death,”J. Clin. Oncol. 17(3):1061-1070, Mar. 1999.
Emerson, D. et al., “In Vivo Antitumor Activity of Two New Seven-Substituted Water-Soluble Camptothecin Analogues,”Cancer Res. 55:603-609, Feb. 1995.
Erickson-Miller, C. et al., “Differential Toxicity of Camptothecin, Topotecan and 9-Aminocamptothecin to Human, Canine, and Murine Myeloid Progenitors (CFU-GM) in Vitro,”Cancer Chemother. Pharmacol. 39:467-472, 1997.
Fenske, D. et al., “Ionophore-Mediated Uptake of CiproFloxacin and Vincristine into Large Unilamellar Vesicles Exhibiting Transmembrane Ion Gradients,”Biochim. et Biophys. Acta 1414:188-204, 1998.
Fraley, R. et al., “Entrapment of a Bacterial Plasmid in Phospholipid Vesicles: Potential for Gene Transfer,”Proc. Natl. Acad. Sci. USA 76(7):3348-3352, Jul. 1979.
Grochow, L. et al., “Pharmacokinetics and Pharmacodynamics of Topotecan in Patients with Advanced Cancer,”Drug Metabolism and Disposition 20(5):706-713, 1992.
Gruner, S.,Liposomes—from Biophysics to Therapeutics, Marcel Dekker, Inc., New York, Ch. 1, “Materials Properties of Liposomal Bilayers,” pp. 1-38.
Hardman, W. et al., “Efficacy of Treatment of Colon, Lung and Breast Human Carcinoma Xenografts with: Doxorubicin, Cisplatin, Irinotecan or Topotecan,”Anticancer Research 19:2269-2274, 1999.
Heath, T., “Covalent Attachment of Proteins to Liposomes,”Methods in Enzymology 149:111-119, 1987.
Hope, M. et al., “Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure. Characterization of Size Distribution, Trapped Volume and Ability to Maintaine a Membrane Potential,”Biochim. et Biophys. Acta 812:55-65, 1985.
Hsiang, Y-H, et al., “Identification of Mammalian DNA Topoisomerase I as an Anticellular Target of the Anticancer Drug Camptothecin,”Cancer Research 48:1722-1726, Apr. 1988.
Hudson, W. et al., “Xenotransplantation of Human Lymphoid Malignancies is Optimized in Mice with Multiple Immunologic Defects,”Leukemia 12:2029-2033, 1998.
Kluin-Nelemans, H. et al., “A New Non-Hodgkin's B-Cell Line (DoHH2) with a Chromosomal Translocation t(14;18) (q32;q21),”Leukemia 5(3):221-224, Mar. 1991.
King, R.E.,Remington's Pharmaceutical Sciences, 17thEd., Mack Publishing Co., Philadelphia, PA, 1985, Part 8, “Pharmaceutical Preparations and Their Manufacture,” pp. 1409-1677.
Leonetti, J-P. et al., “Antibody-Targeted Liposomes Containing Oligodeoxyribonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication,”Proc. Natl. Acad. Sci. USA 87:2448-2451, Apr. 1990.
Madden, T. et al., “The Accumulation of Drugs within Large Unilamellar Vesicles Exhibiting a Proton Gradient: A Survey,”Chem. and Phys. of Lipids 53:37-46, 1990.
Mayer, L. et al., “Characterization of Liposomal Systems Containing Doxorubicin Entrapped in Response to pH Gradients,”Biochim. et Biophys. Acta 1025:143-151, 1990.
Mayer, L. et al., “Techniques for Encapsulating Bioactive Agents into Liposomes,”Chem. and Phys. of Lipids 40:333-345, 1986.
Mayer, L. et al., “Vesicles of Variable Sizes Produced by a Rapid Extrusion Procedure,”Biochim. et Biophys. Acta 858:161-168, 1986.
McCabe, F. et al., “Comparative Activity of Oral and Parenteral Topotecan in Murine Tumor Models: Efficacy of Oral Topotecan,”Cancer Investigation 12(3):308-313, 1994.
Merck Index, 11thed. 1989, Entry Nos. 9887, 9891, & 9893.
O'Leary, J. et al., “Antiangiogenic Effect of Camptothecin Analogues 9-Amino-20(S)-Campthothecin, Topotecan, and CPT-11 Studied in the Mouse Cornea Model,”Clinical Cancer Research 5:181-187, Jan. 1999.
Ormrod, D. et al., “TOPOTECAN—A Review if its Efficacy in Small Cell Lung Cancer,”Drugs 58(3):533-551, Sep. 1999.
Plowman, J. et al.,Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Humana Press Inc., Totowa NJ, 1997, Ch. 6, “Human Tumor Xenograft Models in NCI Drug Development,” pp. 101-125.
Renneisen, K. et al., “Inhibition of Expression of Human Immunodeficiency Virus-1 in Vitro by Antibody-Targeted Liposomes Containing Antisense RNA to theenvRegion,”J

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