Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-02-21
2006-02-21
Barts, Samuel (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000
Reexamination Certificate
active
07001888
ABSTRACT:
Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells.
REFERENCES:
patent: 3694428 (1972-09-01), Hardegger et al.
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4720543 (1988-01-01), McPherson et al.
patent: 4895936 (1990-01-01), Talebian et al.
patent: 5057301 (1991-10-01), Wilbur et al.
patent: 5565434 (1996-10-01), Barfknecht et al.
patent: 5621002 (1997-04-01), Bosslet et al.
patent: 5622936 (1997-04-01), Wiessler et al.
patent: 6037336 (2000-03-01), Hausheer et al.
patent: 6489302 (2002-12-01), Wiessler et al.
patent: 6548484 (2003-04-01), Christian
patent: WO 99-20316 (1999-04-01), None
patent: WO 99/20316 (1999-04-01), None
patent: WO 02/58741 (2002-08-01), None
Tanaka et al. (JP 38007735 (Abstract Only)) (Abstract Sent.).
Fowler et al. (Journal of Labelled Compounds and Radiopharmaceuticals (1979), 16 (1, Second Int. Symp: Radiopharm.), 7-9) (Abstract Sent.). . .
Briasoulis, E. et al. (2000). “Phase I Trial of 6-Hour Infusion of Glufosfamide, a New Alkylating Agent With Potentially Enhanced Selectivity for Tumors That Overexpress Transmembrane Glucose Transporters: A Study of the European Organization for Research and Treatment of Cancer Early Clinical Studies Group,”Journal of Clinical Oncology18(20):3535-3544.
Cantuaria, G. et al. (2000). “Antitumor Activity of a Novel Glyco-Nitric Oxide Conjugate in Ovarian Carcinoma,”Cancer88(2):381-388.
Hou, Y. et al. (2001). “The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor,”Tetrahedron Letters42:825-829.
Ramirez, J. et al. (1996). “Glyco-S-Nitrosothiols, A Novel Class of No-Donor Compounds,”Bioorganic&Medicinal Chemistry Letters6(21):2575-2580.
Seker, H. et al. “Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent,” British Journal of Cancer 82(3):629-634.
Veyhl, M. et al. (1998). “Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1,”Proc. Natl. Acad. Sci. 95:2914-2919.
Matteucci Mark
Rao Photon
Tidmarsh George
Barts Samuel
Date Vandana
Henry Michael C.
Hopkins Mark H.
Kaster Kevin R.
LandOfFree
Compositions and methods for treating cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for treating cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for treating cancer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3642633