Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-02-28
1999-09-07
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142232, 5142238, 5142242, 5142265, 5142292, 5142305, 514255, 514258, 514259, 514296, 514307, 514311, 514336, 514345, 514352, 514354, 514365, 514457, 514367, 514374, 514375, 514385, 514394, 514396, 514397, 514415, 514443, 514535, A61K 31165, A61K 31215, A61K 3133
Patent
active
059487763
ABSTRACT:
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15.ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
REFERENCES:
patent: 5280040 (1994-01-01), Labroo et al.
patent: 5441964 (1995-08-01), Bryant et al.
patent: 5523309 (1996-06-01), Bryant et al.
patent: 5622974 (1997-04-01), Muehl
Chem. abstr. vol. 127, abstract No. 127:17703, Petrie et al. Preparation of (hetero aromatic compounds for treating bone deficit conditions, WO-97/15308 (Eng.).
Chem abstr. vol. 107, abst. No. 107:109578, Watts et al., Studies on the ligand specificity and potential identify of microsomal antiestrogen-binding sites, Mol. Pharmocol. 1987, 31(5), 541-51.
Chem abstr. vol. 108, abstract No. 108:69162, Jordan et al., Effects of antiestrogens on bone in castrated and intact female rats, Breast Cancer Res. Treat. 1987, 10(1), 31-5.
Chem. abstr. vol. 115, abstract No. 115:8533, Schwarz et al. 1,2-diphenyl-1-pyridybut-1-enes--potential antigestrogens. part 1. synthesis Arch. Pharm. 1991, 324(4), 223-9.
Neelam et al. Structure-activity relationship of antiestrogens: A study using triarylbutenone, benzofuran and triayrlfuran analogues as models for triarylethylenes and triarylpropenones. J. Med. chem. 1989, vol. 32, pp. 1700-1707, see entire article.
Von Angerer et al. Studies on heterocycle-based pure estrogen antagonists. Ann. N.Y. Academy Sciences. 1995, vol. 761, pp. 176-191, see especially pp. 178-180.
Mundy, G.R., "Cytokines and Growth Factors in the Regulation of Bone Remodeling," Journal of Bone and Mineral Research (1993) 8(2):S505-S510.
Mundy, G.R., "Regulation of Bone Formation of Bone Morphogenetic Proteins and Other Growth Factors," Clinical Orthopaedics and Related Research (1996) 324:24-28.
Harris, S.E., et al., "Effects of Transforming Growth Factor .beta. on Bone Nodule Formation and Expression of Bone Morphogenetic Protein 2, Osteocalcin, Osteopontin, Alkaline Phosphatase, and Type I Collagen mRNA in Long-Term Cultures of Fetal Rat Calvarial Osteoblasts," Journal of Bone and Mineral Research (1994) 9(6):855-863.
Stein, G.S., et al., "Bone cell differentiation: a functionally coupled relationship between expression of cell-growth- and tissue-specific genes," Current Opinion in Cell Biology (1990) 2:1018-1027.
Urist, M.R., "Bone: Formation by Autoinduction," Science (1965) 150:893-899.
Wozney, J.M., et al., "Novel Regulators of Bone Formation: Molecular Clones and Activities," Science (1988) 242:1528-1534.
Wozney, J.M., "The Bone Morphogenetic Protein Family and Osteogenesis," Molecular Reproduction and Development (1992) 32:160-167.
Baindur Nand
Mundy Gregory R.
Orme Mark W.
Petrie Charles
Robbins Kirk G.
Murashige Kate H.
Osteoscreen Inc.
Reamer James H.
Zymogenetic, Inc.
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