Compositions and methods for topical application of therapeutic

Details Compositions and methods for topical application of therapeutic Compositions and methods for topical application of therapeutic

1996-09-11

1999-01-26

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424487, 424488, 514944, A61K 910, A61K 4732, A61K 4738

Patent

active

058635602

ABSTRACT:
The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.

REFERENCES:
patent: 4731359 (1988-03-01), Swarbrick
patent: 4853439 (1989-08-01), Barabas
patent: 5180576 (1993-01-01), Winston et al.
patent: 5643584 (1997-07-01), Farng et al.
patent: 5705194 (1998-01-01), Wong et al.

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