Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1998-11-30
2000-05-09
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
514859, 514944, A61K 910
Patent
active
060600853
ABSTRACT:
The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.
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Freeman, D.J. et al., "Failure of topical acyclovir in ointment to penetrate human skin" Antimicrobial agents and chemotherapy 29(5):730-732 (May 1986).
Hostynek, J.J. et al., "Human skin penetration by metal compounds" in Dermal Absorption and Toxicity Assessment, Chapter 25, edited by Roberts, M.S. and Walters, K.A., published by Marcel Dekker, Inc., pp. 647-668 (1998).
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