Compositions and methods for tissue specific targeting of...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

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C435S069100, C435S320100, C435S325000, C435S455000, C424S093100

Reexamination Certificate

active

07090837

ABSTRACT:
This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs, lentiviral packaging systems, and lentiviral gene delivery systems. Finally, methods of transducing a cell and methods of targeting a gene to a cell or tissue using the disclosed lentiviral vectors and systems are also provided.

REFERENCES:
Sandrin et al Blood 100(3):823-832, 2002.
Bosch et al J. Gen. Virol. 82:2485-2494, 2001.
Spiegel et al J. Virol. 72(6):5296-5302, 1998.
Juengst BMJ, 326:1410-11, 2003.
Check NATURE 422:7, 2003.
Couzin et al, SCIENCE 307:1028, 2005.
Rosenberg et al, SCIENCE 287:1751, 2000.
Anderson, NATURE 392:25-30, 1998.
Aldovini and Young, “Mutations of RNA and Protein Sequences Involved in Human Immunodeficiency Virus Type 1 Packaging Result in Production of Noninfectious Virus.”J. Virol., 64:1920-1926, 1990.
Chan and Kim, “HIV Entry and Its Inhibition.”Cell, 93:681-684, 1998.
Dull et al., “A Third-Generation Lentivirus Vector with a Conditional Packaging System.”J. Virol., 72:8463-8471, 1998.
Feinberg et al., “The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.”Proc. Natl. Acad. Sci. USA, 88:4045-4049, 1991.
Finer et al., “kat: A High-Efficiency Retroviral Transduction System for Primary Human T Lymphocytes.”Blood, 83:43-50, 1994.
Geigenmuller and Linial, “Specific Binding of Human Immunodeficiency virus Type 1 (HIV-1) Gag-Derived Proteins to a 5′ HIV-1 Genomic RNA Sequence.”J. Virol., 70:667-671, 1996.
Kim et al., “A Short Sequence Upstream of the 5′ Major Splice Site is Important for Encapsidation of HIV-1 Genomic RNA.”Virology, 198:336-340, 1994.
Lamb, “Paramyxovirus Fusion: A Hypothesis for Changes.”Virology, 197:1-11, 1993.
Leavitt et al., “Human Immunodeficiency Virus Type 1 Integrase Mutants Retain In Vitro Integrase Activity yet Fail To Integrate Viral DNA Efficiently during Infection.”J. Virol., 70:721-728, 1996.
Lin et al., “Receptor-Specific Targeting Mediated by the Coexpression of a Targeted Murine Leukemia Virus Envelope Protein and a Binding-Defective Influenza Hemagglutinin Protein.”Hum. Gene Ther., 12:323-332, 2001.
Lin and Cannon, “Use of pseudotype retroviral vectors to analyze the receptor-binding pocket of hemagglutinin from a pathogenic avian influenza A virus (H7 subtype).”Virus Res., 83:43-56, 2002.
Luban and Goff, “Mutational Analysis ofcis-Acting Packaging Signals in Human Immunodeficiency Virus Type 1 RNA.”J. Virol., 68:3784-3793, 1994.
McBride and Panganiban, “The Human Immunodeficiency Virus Type 1 Encapsidation Site Is a Multipartite RNA Element Composed of Functional Hairpin Structures.”J. Virol., 70:2963-2973, 1996.
Miyoshi et al., “Development of a Self-Inactivating Lentivirus Vector.”J. Virol., 72:8150-8157, 1998.
Naldini et al., “Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.”Proc. Natl. Acad. Sci. USA, 93:11382-11388, 1996.
Naldini et al., “In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector.”Science, 272:263-267, 1996.
Ory et al., “A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.”Proc. Natl. Acad. Sci. USA, 93:11400-11406, 1996.
Paillart et al., “A loop-loop “kissing” complex is the essential part of the dimer linkage of genomic HIV-1 RNA.”Proc. Natl. Acad. Sci. USA, 93:5572-5577, 1996.
Vicenzi et al., “An Integration-Defective U5 Deletion Mutant of Human Immunodeficiency Virus Type 1 Reverts by Eliminating Additional Long Terminal Repeat Sequences.”J. Virol., 68:7879-7890, 1994.
Wyatt and Sodroski, “The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens.”Science, 280:1884-1888, 1998.
Zhang et al., “Nascent Human Immunodeficiency Virus Type 1 Reverse Transcription Occurs within an Enveloped Particle.”J. Virol., 69:3675-3682, 1995.
Zhang et al., “Endogenous Reverse Transcription of Human Immunodeficiency Virus Type 1 in Physiological Microenvironments: an Important Stage for Viral Infection of Nondividing Cells.”J. Virol., 70:2809-2824, 1996.
Zufferey et al., “Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery.”J. Virol., 72:9873-9880, 1998.
Zufferey et al., “Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.”Nature Biotechnol., 15:871-875, 1997.

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