Compositions and methods for therapy or prevention of...

Details Compositions and methods for therapy or prevention of... Compositions and methods for therapy or prevention of...

2011-05-31

2011-05-31

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C514S021200

Reexamination Certificate

active

07951359

ABSTRACT:
The present invention relates to the use of IL-6 in compositions and methods for therapy or prevention of chemotherapy-induced neuropathy (CIPN). More specifically, the invention relates to the use of a low dose of IL-6 for the treatment and/or prevention CIPN.

REFERENCES:
patent: 2008/0107621 (2008-05-01), Dreano et al.
patent: WO 03/033015 (2003-04-01), None
McWhinney et al., Platinum neurotoxicity pharmacogenetics, Mol Cancer Ther. 8(1):10-6 (2009).
Quasthoff and Hartung, Chemotherapy-induced peripheral neuropathy, J. Neurol. 249:9-17 (2002).
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Scripture et al., Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives, Curr Neuropharmacol. 4(2):165-72 (2006).
Sioka and Kyritsis. Central and peripheral nervous system toxicity of common chemotherapeutic agents, Cancer Chemother Pharmacol 63:761-767 (2009).
I. G. Obrosova, Diabetes and the periopheral nerve, Biochim. Biophys. Acta 1792:931-940 (2009).

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