Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-06-07
1999-03-02
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514570, A61K 3119
Patent
active
058772138
ABSTRACT:
Compositions and methods of treating anemia, cancer, AIDS, or severs .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.
REFERENCES:
patent: 3973022 (1976-08-01), Goschke
patent: 3976673 (1976-08-01), Pifferi
patent: 3998966 (1976-12-01), Fried et al.
patent: 4028404 (1977-06-01), Bays et al.
patent: 4282214 (1981-08-01), Flora et al.
patent: 4457942 (1984-07-01), Brusilow
patent: 4470970 (1984-09-01), Burzynski
patent: 4720506 (1988-01-01), Munakata et al.
patent: 5254587 (1993-10-01), Burzynski
Burzynski, S.R. et al., Preclinical studies on antineoplaston as2-1 and antineoplason AS2-5, Drugs Exptl. Clin. Res., Supplemental 1, XII:11-16 (1986).
Timothy J. Ley, et al., 5-Azacytidine Selectively Increases .gamma.-globin Synthesis in a Patient with .beta..sup.+ Thalassemia, New England Journal of Medicine, vol. 307:1469-1475 (Dec. 8, 1982).
Michael B. Sporn, et al., Chemoprevention of Cancer with Retinoids, Federation Proceedings, vol. 38:2528-2534 (Oct. 1979).
Richard L. Momparler, et al., Clinical Trial on 5-AZA-2'-Deoxycytidine in Patients with Acute Leukemia, Pharmac. Ther., vol. 30:277-286 (1985).
Gary J. Kelloff, et al., Chemoprevention Clinical Trials, Mutation Research, vol. 267:291-295 (1992).
I. Bernard Weinstein, Cancer Prevention: Recent Progress sand Future Opportunities, Cancer Research, vol. 51:5080s-5085s (1991).
Olli Simell, et al., Waste Nitrogen Excretion Via Amino Acid Acylation: Benzoate and Phenylacetate in Lysinuric Protein Intolerance, Pediatr. Res., vol. 20:1117-1121 (1986).
Neish, et al., Phenylacetic Acid as a Potential Therapeutic Agent for the Treatment of Human Cancer, Experentia, vol. 27:860-861 (1971).
J.A. Stamatoyannopoulos, et al., Therapeutic Approaches to Hemoglobin Switching in Treatment of Hemoglobinopathies, Annu. Rev. Med., vol. 43:497-521 (1992).
Shechter, Y. et al., Hydroxyphenyl Acetate Derivatives Inhibit Protein Tyrosine Kinase Activity and Proliferation in Nb2 Rat Lymphoma Cells and Insulin-Induced Lipogenesis in Rat Adipocytes, Molecular and Cellular Endocrinology, vol. 80, pp. 183-192 (1991).
Marcot et al., Chemical Abstracts, 83, 1975:53278s (1975).
Samid, D. et al., Interferon in Combination with Antitumourigenic Phenyl Derivatives: Potentiation of IFN.alpha. Activity In-Vitro, British J. Haematology, vol. 79, Supp. 1, pp. 81-83 (Oct. 10, 1991).
Ross, Philip D. and Subramanian, S., Inhibition of sickle cell hemoglobin gelation by some aromatic compounds, Biochem. Biophys. Res. Commun., 77:1217-1223 (1977).
Jones, G.L., Anti sickling effects of Betw Di Ethylaminoethylidiphenylpropyl acetate SFK-525-A, Pharmacologist, 20(3):204 (1978).
Erhum, Wilson O., Acetonyl esters of hydroxybenzoic acids as potential antisickling agents, Niger. J. Pharm., 12:285-287 (1981).
Reamer James H.
The United States of America as represented by the Department of
LandOfFree
Compositions and methods for therapy and prevention of cancer, A does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for therapy and prevention of cancer, A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for therapy and prevention of cancer, A will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-423385