Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-01-07
2000-12-26
Hauda, Karen M.
Chemistry: molecular biology and microbiology
Vector, per se
435235, 4241991, 514 44, C12N 1563, C12N 700, A61K 3800, A61K 4800
Patent
active
061657794
ABSTRACT:
A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
REFERENCES:
patent: 5552309 (1996-09-01), March
patent: 5912236 (1999-06-01), Xu et al.
Wills et al. Sep. (1994) Human Gene Ther., vol. 5, 1079-1088.
Hjelmeland et al. (1983) Anal. Biochem., vol. 130, 485-490.
Pinnaduwage et al. (1989) Biochim. Biophys. Acta., vol. 985, 33-37.
Osifchin et al. Mar. (1994) J. Biol. Chem., vol. 269 (9), 6383-6389.
Takahashi et al. Jun. (1991) Proc. Natl. Acad. Sci. USA., vol. 88, 5257-5261.
Miller et al Feb. (1995) FASEB J. 9:190-199.
Marshall, E Aug. 25, (1995) Science 269:1050-1055.
Greney et al (1994) Neurochem. Int. 25:183-191.
Pinnaduwage et al (1989) Biochemica et Biophysica Acta 985:33-37.
Abe, A. et al., "Transduction of a Drug-Sensitive Toxic Gene into Human Leukemia Cell Lines with a Novel Retroviral Vector (43611) ,"Proc. Soc. Exp. Biol. Med. 203:354-359 (1993).
Banjerjee, A. et al., "Changes in Growth and Tumorigenicity Following Reconstitutionof Retinoblastoma Gene Function in Various Human Cancer Cell types by Microcell Transfer of Chromosome 13," Canc. Res. 52:6297-6304 (1992).
Bass, C. et al., "Recombinant Adenovirus-Mediated Gene Transfer to Genitourinary Epithelium in Vitro and In Vivo," Canc. Gene Ther. 2(2) :97-104 (1995).
Blixt et al., "Enhancement of Intracellular Uncoating of Adenovirus in HeLa cells in the Presence of Benzyl Alcohol as a Membrane Fluidizer," Arch. Virol. 129:265-277 (1993).
Brewster et al., Eur. Urol. 25:177-182 (1994).
Cairns et al., "Loss of heterozygosity at the RB Locus is Frequent and Correlates with Muscle Invasion in Bladder Carcinoma," Oncogene 6:2305-2309 (1991).
Cancer Facts and Figures, Amer. Can. Soc. 5-11 (1995).
Fujimoto, K. et al., "Frequent Association of p53 Gene Mutation in invasive Bladder Cancer, " Canc. Res. 52:1393-1398 (1992).
Ginsberg, H.S. et al., "Role of early region 3 (E3) in pathogenesis of adenovirus disease," Proc. Natl. Acad. Sci. U.S.A. 86:3823-3827 (1989).
Good et al., Biochemistry 5:467 (1966).
Goodrich, D.W. et al., "Expression of the Retinoblastoma Gene Product in Bladder Carcinoma Cell Associates with a Low Frequency of Tumor Formation," Canc. Res. 52: 1968-1973 (1992).
Greenberg, R. et al., "Intravesical AD 32 (N-Trifluoroacetyladriamycin-14-Valerate) in the Treatment of Patients with Refractory Bladder Carcinoma-Clinical Efficacy, Pharmacology, and Safety," Proc. Amer. Urol. Assoc. 153 Supp 233A:19 (1995).
Hemstrom, C. et al., "Gene Product of Region E4 of Adenovirus Type 5 Modulates Accumulation of Certain Viral Polypeptides," J. Virol. 62(9) :3258-3265 (1988).
Li, Q. et al., "Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy," Human Gene Ther. 4:403-409 (1993).
Monson, F.C. et al., "Indigocarmine as a Quantitative Indicator of Urothelial Integrity," J. Urol. 145:842-845 (1991).
Morris, B.D. et al., "Adenoviral-Mediated Gene Transfer to Bladder In Vivo," J. Urol. 152:506-509 (1994).
Parsons, C.L. et al., "Bladder Surface Gycosaminoglycans: An Epithelial Permeability Barrier," J. Urol. 143:139-142 (1990).
Rosenberg, S.A., "The Immunotherapy and Gene Therapy of Cancer," J. Clin. Oncol. 10 (2) : 180-199 (1992).
Sandberg, J.W. et al., "Improving Access to Intestinal Stem Cells as a Step Toward Intestinal Gene Transfer," Hum. Gene Ther. 5:323-329 (1994).
Spandidos, D.A. et al., "Expression of the Normal H-ras1 Gene Can Suppress the Transformed and Tumorigenic Phenotypes Induced by mutant ras Genes," Anticancer Res. 10:1543-1554 (1990).
Takahashi, R. et al., "The Retinoblastoma Gene Functions as a Growth and Tumor Suppressor in Human Bladder Carcinoma Cells," Proc. Natl. Acad. Sci. U.S.A. 88:5257-5261 (1991).
Wills, K.N. et al., "Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer," Human Gene Ther. 5:1079-1088 (1994).
Wills, K.N. et al., "Gene therapy for hepatocellular carcinoma: Chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene," Canc. Gene Ther. 2(3) :191-197 (1995).
Engler Heidrun
Huyghe Bernard G.
Maneval Daniel C.
Shabram Paul
Beckerleg Anne Marie S.
Canji Inc.
Hauda Karen M.
LandOfFree
Compositions and methods for therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for therapeutic use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-993564