Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-06-06
1998-11-03
Feisee, Lila
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 2, 530351, 530381, 424 855, 424 851, A61K 4505, A61K 3800
Patent
active
058304487
ABSTRACT:
The invention concerns a method for inhibiting the growth and/or causing regression of tumors by administering a therapeutically effective dose of a procoagulant and a cytokine, preferably TNF-.beta., TNF-.alpha. and/or IL-1. In a specific aspect, the invention concerns a method for tumor treatment by the administration of a therapeutically effective amount of a thrombomodulin inhibitor and a cytokine. The invention also concerns thrombomodulin inhibitors and pharmaceutical compositions used in the course of these treatments.
REFERENCES:
Nishigaki et al., "Role of tissue factor in the antitumor effect of recombinant human tumor necrosis factor-.alpha. in mice" Anticancer Research 14:2573-2576.
Schwager and Jungi, "Effect of human recombinant cytokines on the induction of macrophage procoagulant activity" Blood 83(1):152-160 (1994).
Tijburg et al., "Activitation of the coagulation mechanism on tumor necrosis factor-stimulated cultured endothelial cells and their extracellular matrix" Journal of Biological Chemistry 266(18):12067-12074 (1991).
Stryer, Biochemistry, W.H. Freeman & Co, NY, 1988 see p. 248.
Dreger Ginger R.
Feisee Lila
Genentech Inc.
Ungar Susan
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