Compositions and methods for the treatment of the symptoms of hi

Details Compositions and methods for the treatment of the symptoms of hi Compositions and methods for the treatment of the symptoms of hi

1974-01-28

1976-06-22

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424248, 424251, 424267, A61K 31535

Patent

active

039652572

ABSTRACT:
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##
Wherein R represents hydrogen or hydroxy; R.sup.1 represents hydrogen; or R and R.sup.1 taken together form a second bond between the carbon atoms bearing R and R.sup.1 ; n is a positive whole integer of from 1 to 3; Z represents thienyl, phenyl, or substituted phenyl wherein the substituents on the substituted phenyl may be attached at the ortho, meta, or para positions of the phenyl ring and are selected from halogen, a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, a lower alkoxy group of from 1 to 4 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)alkylpiperazino. Pharmaceutically acceptable acid addition salts and individual optical isomers of compounds of the above formula are also included as a part of this invention.

REFERENCES:
patent: 2739968 (1956-03-01), Sperber et al.
patent: 3068237 (1962-12-01), Rorig
patent: 3080372 (1963-03-01), Janssen
patent: 3097209 (1963-07-01), Janssen
patent: 3122555 (1964-02-01), Janssen
Stedman's Medical Dictionary, 21st Edition, (1969), p. 52.

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