Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-02-29
2010-06-08
Carr, Deborah D (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S562000, C514S564000, C514S566000, C514S557000, C548S183000, C554S051000, C554S053000, C554S063000, C554S213000, C554S223000, C554S227000, C562S557000, C562S564000, C562S565000, C562S567000, C562S587000
Reexamination Certificate
active
07732470
ABSTRACT:
Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
REFERENCES:
patent: 6890925 (2005-05-01), Ingraham et al.
patent: 2006/0148744 (2006-07-01), Hammock et al.
Falck et al., “11, 12-Epoxyeicosatrienoic Acid (11, 12-EET): Structural Determinants for Inhibition of TNF-alpha-Induced VCAM-1 Expression,” Bioorganic & Medicinal Chemistry Letter 13, 2003, 4011-4014.
Imig et al., “Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid,” Journal of Hypertension, 2001, 19:983-992.
Imig, “Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases,” Am J Physiol Renal Physiol, 2005, 289:F496-F503.
Zhao et al., “Decreased Renal Cytochrome P450 2C Enzymes and Impaired Vasodilation Are Associated With Angiotensin Salt-Sensitive Hypertension,” Hypertension, 2003, 41:709-714.
Falck John R.
Imig John D.
Board of Regents , The University of Texas System
Carr Deborah D
Medical College of Georgia Research Institute
Sutherland & Asbill & Brennan LLP
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