Compositions and methods for the treatment of Pierce's disease

Details Compositions and methods for the treatment of Pierce's disease Compositions and methods for the treatment of Pierce's disease

2004-05-14

2008-10-07

Ketter, James (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Plant, seedling, plant seed, or plant part, per se

Higher plant, seedling, plant seed, or plant part

C435S069100, C435S252330, C435S320100, C435S419000, C435S348000, C530S350000, C536S023500

Reexamination Certificate

active

07432419

ABSTRACT:
Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogenXylella fastidiosaare provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenicVitus vineferaplants expressing xylem-secreted anti-microbial chimeras are also provided.

REFERENCES:
patent: 2004/0052814 (2004-03-01), Shi et al.
Weng et al. Cloning and expression of the cecropin B thanatin hybrid antimicriobial peptided inE. coliChinese journal of biotechnology May 2002 18(3) pp. 352-355.
Shin et al. Structure-antibacterial antitumor and hemolytic activity relations hips of cecropin A -magainin2 and Cecropim A-melittin hybrid peptides Journal of Peptide Research 1999 53(1) 82-90, abstract only.
Accession No. AAP80335 1990.
Boman, 2003, J. Int. Med. 254: 197-215.
Raj & Dentino, 2002, FEMS Microbiol. Lett. 206: 9.
Hancock, 2001, The LANCET 1: 156.
Davis et al., 1978, Science 199: 75-77.
Chang et al., 1993, Curr. Microbiol. 27: 137-142.
Goheen et al., 1973, Phytopathology 63: 341-345.
Hopkins, 1989, Annu. Rev. Phytopathol. 27: 271-290.
Wells et al., 1983, Phytopathology 73: 859-862.
De Lima, et al., 1996, Fitopatologia Brasileira 21(3).
Purcell and Saunders, 1999, Plant Dis. 83: 825-830.
Hendson, et al., 2001, Appl. Environ. Microbiol 67: 895-903.
Purcell and Hopkins, 1996, Annu. Rev. Phytopathol. 34: 131-151.
Briansky et al., 1983, Phytopathology 73: 530-535.
Purcell et al., 1979, Science 206: 839-841).
Hill and Purcell, 1997, Phytopathology 87: 1197-1201.
Garcia et al., 1998, Infection and Immunity 66:1408-12.
Lusitani et al., 2002, J. Infect. Dis. 185: 797-804.
Miyasaki and Bodeau, 1991, Infection and Immunity 59: 3015-20.
Breuning et al., 2002, Proceedings, Pierce's Disease Research Symposium, Eds. Athar-Tariq et al., San Diego, CA.
Epand and Vogel, 1999, Biochimica Biophysica Acta 1462: 11-28.
Bechinger, 1997, J. Membrane Biol. 156: 197-211.
Hong et al., 2003, Antimicrobial Agents Chemother. 47: 1-6.
Broekaert et al., 1997, Crit. Rev. Plant Sci. 16: 297-323.
Bonmatin et al., 1992, J. Biomol. NMR 2: 235-256.
Fehlbaum et al., 1994, J. Biol. Chem. 269: 33159-33163.
Thomma et al., 2003, Planta 216: 193-202.
Segura et al., 1998, FEBS Letters 435: 159-162.
Boman et al., 1991, Cell 65: 205-207.
Boman et al., 1991, Eur. J. Biochem. 201: 23-31.
Wade et al., 1990, Proc. Natl. Acad. Sci. USA 87: 4761-4765.
Vaara and Vaara,1994, Antimicrobial Agents Chemother 38:2498-2501.
Mason et al., 1996, Proc. Natl. Acad. Sci. USA 93: 5335-5340.
Decendit et al., 1996, Biotechnol. Lett. 18: 659-662.
Szankowski et al., 2003 Plant Cell Rep. 22: 141-149.
Hiatt et al., 1989, Nature 342: 76-78.
Kumagai et al., 1993, Proc. Natl. Acad. Sci. USA 90: 427-430.
Verch et al., 2004, Cancer Immunol. Immunother. 53: 92-99.
Verch et al., 1998, J. Immunol. Methods 220: 69-75.
Pieters, 2001, Current Opinion Immunol. 13:37-44.
Baquero and Blazquez, 1997, Trends Ecol. Evol. 12:482-487.
Sharma v. Surolia, 1997, Journal of Molecular Biology 267: 433-445.
Barre et al., 2001, Biochimie 83:645-651.
Feinberg et al., 2001, Science 294: 2163-2167.
Rep et al., 2003, FEBS Letters 534:82-86.
Peschel, 2002, Trends Microbiol. 10:179.
Belmonte, US Patent Application 20030004065.
Meredith et al., 2003, Proceedings of the 2003 Pierce's Disease Research Symposium, Calif. Dept. Food & Agriculture, p. 23-25.

Affiliated with

Also associated with

Rating

Compositions and methods for the treatment of Pierce's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for the treatment of Pierce's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the treatment of Pierce's disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4006821