Compositions and methods for the treatment of hemophilia A

Details Compositions and methods for the treatment of hemophilia A Compositions and methods for the treatment of hemophilia A

2007-05-01

2007-05-01

Nashed, Nashaat T. (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S04400A, C435S320100, C530S350000, C530S383000, C536S023100

Reexamination Certificate

active

10445235

ABSTRACT:
Improved materials and methods for the treatment of Hemophilia A are provided.

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Antonarakis et al., Molecular Genetics of Hemophilia A in Man (Factor VIII Deficiency), Mol. Biol. Med. (1987) 4, pp. 81-94.
Berntorp, Second Generation, B-Domain Deleted Recombinant Factor VIII, Thrombosis and Hemostasis, (1997) 78(1), pp. 256-260.
Brinkhous et al., Purified human factor VIII procoagulant protein: Comparative hemostatic response after infusions into hemophilic and Von Willebrand disease dogs, PNAS (1985) 82, pp. 8752-8756.
Lind et al., Novel forms of B-domain-deleted recombinant factor VIII molecules. Construction and biochemical characterization, Eur. J. Biochem. (1995) 232, 19-27.
Lusher et al., Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A, The New England Journal of Medicine (1993), 328(7), pp. 453-459.
Pittman et al., A2 Domain of Human Recombinant-Derived Factor VIII is Required for Procoagulant Activity but not for Thrombin Cleavage, Blood (1992), 79(2), pp. 389-397.
Sandberg et al., Structural and Functional Characterization of B-Domain Deleted Recombinant Factor VIII, Seminars in Hematology, (2001) 38(2), pp. 4-12.
Toole et al., Molecular cloning of a cDNA encoding human anti-haemophillic factor, Nature (1984) 312(22), pp. 342-347.
Vehar et al., Structure of human factor VIII, Nature (1984) 312(22), pp. 337-342.
Wood et al., Expression of active human factor VIII from recombinant DNA clones, Nature (1984) 312(22), pp. 330-337.

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