Compositions and methods for the treatment of colorectal cancer

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

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06914067

ABSTRACT:
This invention relates to compositions comprising thalidomide and irinotecan, which can be used in the treatment or prevention of colorectal cancer. The invention also relates to methods of treating or preventing colorectal cancer which comprise the administration of thalidomide and irinotecan to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of irinotecan which comprise the administration of thalidomide to a patient in need of such reduction or avoidance.

REFERENCES:
patent: 4604463 (1986-08-01), Miyasaka et al.
patent: 5385901 (1995-01-01), Kaplan et al.
patent: 5593990 (1997-01-01), D'Amato
patent: 5629327 (1997-05-01), D'Amato
patent: 5643915 (1997-07-01), Andrulis, Jr. et al.
patent: 5654312 (1997-08-01), Andrulis, Jr. et al.
patent: 5712291 (1998-01-01), D'Amato
patent: WO 94/20085 (1994-09-01), None
Govindarajan et al., The Lancet, vol. 356, pp. 566-567, Aug. 12, 2000.
Cao et al.British Journal of Cancer80:716-723 (1999).
Avgeropoulos et al.,The Oncologist4:209-224 (1999).
Bach et al.,Acta Pathol. Microbiol. Scand.59:491-499 (1963).
Bach et al.,The Lancet71:1271 (1963).
Braun et al.,Biochem. Biophys. Res. Comm.98(4):1029-1034 (1981).
Chaundry et al.,Cancer Res.26:1884-1886 (1966).
Costa et al.,Blood92 (10:suppl. 1):235b (1998).
Cunningham et al.,The Lancet352(9138):1413-1418 (1998).
D'Amato et al.,Proc. Natl. Acad. Sci.91:4082-4085 (1994).
De et al.,J. Pharm. Sci.64(2):262-266 (1975).
DiPaolo et al.,Proc. Soc. Exp. Biol. And Med.114:384-387 (1963).
DiPaolo et al.,ScienceJun. 26, 1964:1583 (1964).
DiPaolo et al.,Cancer Chemo. Reports29:99-102 (1963).
Ehrenpreis et al.,Gastroenterology117:1271-1277 (1999).
Gershbein,Riv. Pathol. Nerv. Ment.87(4):88-92 (1966).
Grabstald et al.,Clin. Pharmacol. And Ther.6(3):298-302 (1965).
Hatfill et al.,Leuk. Res.15(2-3):129-136 (1991).
Koch,Prog. Med. Chem.22:165-242 (1985).
Lenicque,Acta Zool.48:128-139 (1967).
Marx et al.,Proc. Am. Soc. Clin. Oncology18:454a (1999).
McCann,Drug Topics41-42 (Jun. 21, 1999).
McHugh et al.,Clin. Exper. Immunol.,99:160-167 (1995).
Miura et al.,Experientia26:305-306 (1970).
Mohri et al.,Chem. Pharm. Bull.16:2289-2292 (1968).
Moller et al.,J. Immunol.159:5157-5161 (1997).
Moreira et al.,J. Expr. Med.177:1675-1680 (1993).
Muckter,Antimicrobial Agents and Chemotherapy531-538 (1965).
Mummery et al.,Toxicol. Lett.18(3):201-209 (1983).
Olson et al.,Clin. Pharmacol. And Ther.6:293-297 (1965).
Physician's Desk Reference, 2412-2418 (54thed., 2000).
Physician's Desk Reference, 911-916 (54thed., 2000).
Pitot et al.,J. Clin. Oncology15(8):2910-2919 (1997).
Robbins et al.,Basic Pathology2, nded., W.B. Saunsers Co., Philadelphia, pp68-79 (1976).
Roe et al.,Nature200:1016-1017 (1963).
Rothenberg,Annals of Oncology8:837-855 (1997).
Rothenberg et al.,Cancer85(4):786-795 (1999).
Rothenberg et al.,J. Clin. Oncology14(4):1128-1135 (1996).
Singhal et al.,New England J. Med.341(21):1565-1571 (1999).
Sugiura et al.,GANN55:57-60 (1964).
Vasiliauskas et al.,Gastroenterology117:1278-1287 (1999).
Villa et al.,Haematol. Latina6:217-221 (1963).
Villa et al.,The Lancet, Mar. 30, 1963, 725 (1963).
Woodyatt,The Lancet, Apr. 7, 1962, 750 (1962).
Zwart,Arzneim-Forsch.16(12):1688-1689 (1966).

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