Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1996-12-24
1999-03-30
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
A61K 3112
Patent
active
058890629
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to active compounds and formulations for care of aged skin and for prophylaxis and treatment of chronological aging of the skin which may additionally be intensified or accelerated by exogenous factors.
Chronological aging of the skin is caused, for example, by endogenous, genetically determined factors. In the epidermis and dermis, the following aging-related structural damage and dysfunctions, which can also fall under the term "senile xerosis", occur:
Exogenous factors, such as UV light and chemical noxae, may have a cumulative action and, for example, accelerate or supplement the endogenous aging processes. In the epidermis and dermis, for example, the following structural damage and dysfunctions in the skin, which go beyond the extent and quality of damage during chronological aging, occur in particular due to exogenous factors: example senile keratosis) and
The present invention particularly relates to products for care of skin aged in a natural manner, and for treatment of the secondary damage of aging caused by light, in particular the phenomena listed under a) to g).
Products for the care of aged skin are known per se. They comprise, for example, retinoids (vitamin A acid and/or derivatives thereof) or vitamin A and/or derivatives thereof. However, the extent of their action on structural damage is limited. Furthermore, during product development, there are considerable difficulties in stabilizing the active compounds adequately against oxidative decay. The use of products comprising vitamin A acid moreover often causes severe erythematous skin irritations. Retinoids can therefore be employed only in low concentrations.
Cosmetic formulations with coenzyme Q-10 which are suitable for treatment of skin diseases, for prophylaxis of dystrophic and dysmetabolic states of the skin and for use on chemical and physical respiratory damage or in cases of delayed respiration associated with age and wear are furthermore known from DE-A-33 09 850.
Japanese Laid-Open Specification 58,180,410 describes the suitability of coenzyme Q-10 for cosmetics. It is said to activate skin cell metabolism and suppress oxidation. As a result, coenzyme Q-10 has an important function in the prevention of skin damage due to UV radiation and the prevention of aging of the skin. Roughness of the skin of 20- to 40-year olds is improved by giving the skin moisture.
The object of the present invention was thus to discover ways of avoiding the disadvantages of the prior art. In particular, the action of eliminating the damage associated with endogenous, chronological and exogenous aging of the skin and prophylaxis should be permanent, lasting and without the risk of side effects.
These objects are achieved by the invention.
The invention relates to topical formulations having a content of one compound or several compounds from the group consisting of ubiquinones and derivatives thereof in combination with a content of one compound or several compounds from the group consisting of plastoquinones and derivatives thereof, or formulations having a content of one compound or more compounds from the group consisting of plastoquinones and derivatives thereof (as only one group of active compounds).
The topical formulations according to the invention can be cosmetic or dermatological formulations. They are preferably used, as are also the active compounds, for prophylaxis and/or treatment of aging of the skin of chronological and/or exogenous origin.
The invention also relates to the use of one compound or several compounds from the group consisting of ubiquinones and derivatives thereof in combination with one compound or several compounds from the group consisting of plastoquinones and derivatives thereof, or the use of one compound or several compounds from the group consisting of plastoquinones and derivatives thereof, in each case for prophylaxis and/or treatment of aging of the skin of chronological and/or exogenous origin.
"Ubiquinones" and "plastoguinones" here also mean "ubiquinones and derivatives there
REFERENCES:
patent: 3629409 (1971-12-01), Gregory
patent: 5378461 (1995-01-01), Neigut
Hoppe Udo
Sauermann Gerhard
Schreiner Volker
Steiger Klaus-Michael
Beiersdorf AG
Schenkman Leonard
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