Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2006-02-28
2006-02-28
Schultz, James (Department: 1635)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C514S04400A, C514S002600
Reexamination Certificate
active
07005139
ABSTRACT:
The invention provides compositions containing an effective amount of a therapeutic agent encapsulated in a liposome coupled to a desialyated glycoprotein, e.g., desialyated glycoprotein-α1. This invention further provides methods for the targeted delivery of a therapeutic agent to a tissue expressing asialoglycoprotein receptors by delivery to the tissue an effective amount of a composition containing an effective amount of the agent encapsulated in a liposome coupled to a desialyated glycoprotein, e.g., desialyated glycoprotein-α1. Also provided by this invention is a method for inhibiting the proliferation of liver cancer by administering to a subject in need of such therapy an effective amount of a composition containing doxorubicin encapsulated in desialyated glycoprotein-α1 coupled to a liposome.
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Tsang Shui Ying
Wong Jeffrey Tze Fei
Baker & McKenzie LLP
Hong Kong University of Science and Technology
Schultz James
LandOfFree
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