Compositions and methods for the synthesis and assay of enkephal

Details Compositions and methods for the synthesis and assay of enkephal Compositions and methods for the synthesis and assay of enkephal

1993-10-12

1998-07-14

Grimes, Eric

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435212, A61K 3848, C12N 948

Patent

active

057800251

ABSTRACT:
DNA isolates coding for enkephalinase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of enkephalinase for use in therapeutic or diagnostic compositions. Enkephalinase assays are facilitated by novel enkephalinase substrates.

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Skidgel et al., Peptides 5:769-776 (1984).
Bleecker et al., Amer. J. Med. 81(5A):93-102 (1986).
Kerr, M.A., et al., "The Purification and Specificity of a Neutral Endopeptidase from Rabbit Kidney Brush Border." Biochem. J., 137:477-488 (1974).

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