Compositions and methods for the regulation of homocysteine...

Details Compositions and methods for the regulation of homocysteine... Compositions and methods for the regulation of homocysteine...

2005-01-26

2008-09-30

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S042000, C514S045000, C514S048000

Reexamination Certificate

active

07429569

ABSTRACT:
Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that reduce the production of homocysteine and either re-methylate homocysteine back to S-adenosylmethionine, or facilitate its conversion downstream to cystathione. The method of the invention may be achieved by administering 5-methyl tetrahydrofolate, methylcobalamin, and one or more compounds selected from the group consisting of betaine, pyridoxal-5-phosphate, N-acetyl-cysteine, and other cofactors.

REFERENCES:
patent: 5716941 (1998-02-01), Rabinoff
patent: 5922704 (1999-07-01), Bland
patent: 6503947 (2003-01-01), Lipton et al.
Jenkins et al. Am. J. Clin. Nutr. (2002), vol. 76, pp. 365-372.

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