Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1994-10-07
1998-05-05
Loring, Susan A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435325, 435340, 435 732, 435342, 4241501, 4241511, 5303881, 5303884, 5303886, 530350, 5303871, C12P 2108, C07K 1612, A61K 3902, A61K 39395
Patent
active
057472947
ABSTRACT:
Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme disease as caused by infection with B. burgdorferi. Anti-OspA and anti-OspB antibodies that are effective to treat or protect against Lyme disease as caused by infection with B. burgdorferi. A screening method for the selection of those OspA and OspB polypeptides and anti-OspA and anti-OspB antibodies that are useful for the prevention and detection of Lyme disease. Diagnostic kits including OspA and OspB polypeptides or antibodies directed against such polypeptides.
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Barthold Stephen W.
Fikrig Erol
Flavell Richard A.
Kantor Fred S.
Gunnison, Esq. Jane T.
Haley, Jr. Esq. James F.
Loring Susan A.
Yale University
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