Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2011-04-26
2011-04-26
Pak, Michael (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C530S399000, C530S350000
Reexamination Certificate
active
07932364
ABSTRACT:
The present invention relates to mutants of human growth hormone, which contain newly introduced N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
REFERENCES:
patent: 4055635 (1977-10-01), Green et al.
patent: 4088538 (1978-05-01), Schneider
patent: 4179337 (1979-12-01), Davis et al.
patent: 4385260 (1983-05-01), Watts et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4414147 (1983-11-01), Klibanov
patent: 4438253 (1984-03-01), Casey et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4565653 (1986-01-01), Ives et al.
patent: 4806595 (1989-02-01), Noishiki et al.
patent: 4826945 (1989-05-01), Cohn et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4879236 (1989-11-01), Smith et al.
patent: 4925796 (1990-05-01), Bergh et al.
patent: 5032519 (1991-07-01), Paulson et al.
patent: 5104651 (1992-04-01), Boone et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5147788 (1992-09-01), Page et al.
patent: 5153265 (1992-10-01), Shadle et al.
patent: 5154924 (1992-10-01), Friden
patent: 5169933 (1992-12-01), Anderson et al.
patent: 5182107 (1993-01-01), Friden
patent: 5194376 (1993-03-01), Kang
patent: 5202413 (1993-04-01), Spinu
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5324663 (1994-06-01), Lowe
patent: 5324844 (1994-06-01), Zalipsky
patent: 5342940 (1994-08-01), Ono et al.
patent: 5346696 (1994-09-01), Kim et al.
patent: 5352670 (1994-10-01), Venot
patent: 5369017 (1994-11-01), Wong et al.
patent: 5374541 (1994-12-01), Wong
patent: 5374655 (1994-12-01), Kashem et al.
patent: 5405753 (1995-04-01), Brossmer
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5432059 (1995-07-01), Bean
patent: 5446090 (1995-08-01), Harris
patent: 5492841 (1996-02-01), Craig
patent: 5527527 (1996-06-01), Friden
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5545553 (1996-08-01), Gotschlich
patent: 5583042 (1996-12-01), Roth
patent: 5605793 (1997-02-01), Stemmer
patent: 5614184 (1997-03-01), Sytkowski et al.
patent: 5621039 (1997-04-01), Hallahan et al.
patent: 5629384 (1997-05-01), Veronese et al.
patent: 5635603 (1997-06-01), Hansen et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5646113 (1997-07-01), Attie et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5672683 (1997-09-01), Friden et al.
patent: 5705367 (1998-01-01), Gotschlich
patent: 5716812 (1998-02-01), Withers et al.
patent: 5728554 (1998-03-01), Bayer et al.
patent: 5770420 (1998-06-01), Lowe et al.
patent: 5798233 (1998-08-01), Gotschlich
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5824778 (1998-10-01), Ishikawa et al.
patent: 5824864 (1998-10-01), Fox et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5833988 (1998-11-01), Friden
patent: 5834251 (1998-11-01), Maras et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5849535 (1998-12-01), Cunningham et al.
patent: 5858751 (1999-01-01), Paulson et al.
patent: 5858752 (1999-01-01), Seed et al.
patent: 5876980 (1999-03-01), DeFrees et al.
patent: 5922577 (1999-07-01), Defrees et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5945314 (1999-08-01), Prieto et al.
patent: 5945322 (1999-08-01), Gotschlich
patent: 5955347 (1999-09-01), Lowe
patent: 5962294 (1999-10-01), Paulson et al.
patent: 5969040 (1999-10-01), Hallahan et al.
patent: 5977307 (1999-11-01), Friden
patent: 6010999 (2000-01-01), Daley et al.
patent: 6015555 (2000-01-01), Friden
patent: 6030815 (2000-02-01), DeFrees et al.
patent: 6037452 (2000-03-01), Minamino et al.
patent: 6057292 (2000-05-01), Cunningham et al.
patent: 6087325 (2000-07-01), Meers et al.
patent: 6096512 (2000-08-01), Elhammer et al.
patent: 6113906 (2000-09-01), Greenwald et al.
patent: 6117651 (2000-09-01), Schultz et al.
patent: 6166183 (2000-12-01), Ishikawa et al.
patent: 6183738 (2001-02-01), Clark
patent: 6261805 (2001-07-01), Wood
patent: 6268193 (2001-07-01), Lowe
patent: 6342382 (2002-01-01), Gotschlich
patent: 6348558 (2002-02-01), Harris et al.
patent: 6362254 (2002-03-01), Harris et al.
patent: 6376604 (2002-04-01), Kozlowski
patent: 6399336 (2002-06-01), Paulson et al.
patent: 6399337 (2002-06-01), Taylor et al.
patent: 6440703 (2002-08-01), DeFrees
patent: 6465220 (2002-10-01), Hassan et al.
patent: 6531121 (2003-03-01), Brines et al.
patent: 6555346 (2003-04-01), Kretzdorn et al.
patent: 6555660 (2003-04-01), Nissen et al.
patent: 6586398 (2003-07-01), Kinstler et al.
patent: 6692931 (2004-02-01), Reutter et al.
patent: 6693183 (2004-02-01), Natsuka et al.
patent: 6716626 (2004-04-01), Itoh et al.
patent: 6743896 (2004-06-01), Filpula et al.
patent: 6780624 (2004-08-01), Gotschlich
patent: 6800740 (2004-10-01), Cunningham et al.
patent: 6949372 (2005-09-01), Betenbaugh et al.
patent: 7125843 (2006-10-01), DeFrees et al.
patent: 7138371 (2006-11-01), DeFrees et al.
patent: 7157277 (2007-01-01), DeFrees et al.
patent: 7173003 (2007-02-01), DeFrees et al.
patent: 7179617 (2007-02-01), DeFrees et al.
patent: 7202208 (2007-04-01), Papadimitriou
patent: 7214660 (2007-05-01), DeFrees et al.
patent: 7226903 (2007-06-01), DeFrees et al.
patent: 7229962 (2007-06-01), Chung et al.
patent: 7235638 (2007-06-01), Persson
patent: 7265084 (2007-09-01), DeFrees et al.
patent: 7265085 (2007-09-01), DeFrees et al.
patent: 7276475 (2007-10-01), DeFrees et al.
patent: 7297511 (2007-11-01), DeFrees et al.
patent: 7304150 (2007-12-01), Egrie et al.
patent: 7338933 (2008-03-01), DeFrees et al.
patent: 7368108 (2008-05-01), DeFrees et al.
patent: 7399613 (2008-07-01), DeFrees et al.
patent: 7405198 (2008-07-01), DeFrees et al.
patent: 7416858 (2008-08-01), DeFrees et al.
patent: 7439043 (2008-10-01), DeFrees et al.
patent: 7473680 (2009-01-01), DeFrees et al.
patent: 7524813 (2009-04-01), Zundel et al.
patent: 7691603 (2010-04-01), DeFrees
patent: 7696163 (2010-04-01), DeFrees et al.
patent: 7795210 (2010-09-01), DeFrees et al.
patent: 7803777 (2010-09-01), DeFrees
patent: 2002/0016003 (2002-02-01), Saxon et al.
patent: 2002/0019342 (2002-02-01), Bayer
patent: 2002/0037841 (2002-03-01), Papadimitriou
patent: 2002/0115833 (2002-08-01), Burg et al.
patent: 2002/0137134 (2002-09-01), Gerngross et al.
patent: 2002/0142370 (2002-10-01), Paulson et al.
patent: 2002/0150981 (2002-10-01), Canfield
patent: 2002/0168323 (2002-11-01), Gonda et al.
patent: 2002/0182586 (2002-12-01), Morris et al.
patent: 2003/0027257 (2003-02-01), Iatrou et al.
patent: 2003/0040037 (2003-02-01), Bayer
patent: 2003/0124645 (2003-07-01), Paulson et al.
patent: 2003/0166212 (2003-09-01), Taylor et al.
patent: 2003/0166525 (2003-09-01), Hoffmann et al.
patent: 2003/0180835 (2003-09-01), Bayer
patent: 2003/0186850 (2003-10-01), Clausen et al.
patent: 2003/0195338 (2003-10-01), Chung et al.
patent: 2003/0207406 (2003-11-01), Johnson et al.
patent: 2004/0043446 (2004-03-01), DeFrees et al.
patent: 2004/0063911 (2004-04-01), DeFrees et al.
patent: 2004/0077836 (2004-04-01), DeFrees et al.
patent: 2004/0082026 (2004-04-01), DeFrees et al.
patent: 2004/0102607 (2004-05-01), Danishefsky et al.
patent: 2004/0115168 (2004-06-01), DeFrees et al.
patent: 2004/0126838 (2004-07-01), DeFrees et al.
patent: 2004/0132640 (2004-07-01), DeFrees et al.
patent: 2004/0136955 (2004-07-01), Barker
patent: 2004/0137557 (2004-07-01), DeFrees et al.
patent: 2004/0197875 (2004-10-01), Hauser et al.
patent: 2005/0026266 (2005-02-01), Clausen et al.
patent: 2005/0031584 (2005-02-01), DeFrees et al.
patent: 2005/0064540 (2005-03-01), Defrees et al.
patent: 2005/0100982 (2005-05-01), DeFrees et al.
patent: 2005/0106658 (2005-05-01), DeFrees et al.
patent: 2005/0118672 (2005-06-01), DeFrees et al.
patent: 2005/0143292 (2005-06-01), DeFrees et al.
patent: 2005/0
Clausen Henrik
DeFrees Shawn
Leydig , Voit & Mayer, Ltd.
Novo Nordisk A S
Pak Michael
LandOfFree
Compositions and methods for the preparation of human growth... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for the preparation of human growth..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the preparation of human growth... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2638289